2. Epigenetics
  3. Histone Methyltransferase
  4. SET7-IN-DC21

SET7-IN-DC21 is a selective, potent SET7 inhibitor (IC50 = 15.93 μM; KD = 18.00 μM). SET7-IN-DC21 has good selectivity for several other epigenetic targets, such as SUV39H1, G9a, NSD1, DOT1L and MOF. SET7-IN-DC21 can be used for the researches of cancer, infection, inflammation, metabolic and cardiovascular disease, such as breast cancer.

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SET7-IN-DC21

SET7-IN-DC21 Chemical Structure

CAS No. : 2567886-53-5

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SET7-IN-DC21 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

SET7-IN-DC21 is a selective, potent SET7 inhibitor (IC50 = 15.93 μM; KD = 18.00 μM). SET7-IN-DC21 has good selectivity for several other epigenetic targets, such as SUV39H1, G9a, NSD1, DOT1L and MOF. SET7-IN-DC21 can be used for the researches of cancer, infection, inflammation, metabolic and cardiovascular disease, such as breast cancer[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
25.84 μM
Compound: DC21
Antiproliferative activity against human MCF7 cells expresses endogenous ER by Cell Titer-Glo based luminescence assay
Antiproliferative activity against human MCF7 cells expresses endogenous ER by Cell Titer-Glo based luminescence assay
[PMID: 32173197]
In Vitro

SET7-IN-DC21 (0.5-2.5 μM, 72 h) inhibits the proliferation of MCF7 cells in a dose-dependent manner (IC50 = 25.84 μM), and has little effect on the proliferation of normal cells, including normal embryonic lung fibroblast cell line MRC-5 and umbilical vascular endothelial cell line HUV-EC-C[1].
SET7-IN-DC21 (6.25-200 μM, 72 h) can decrease the stability of ERα, which leads to a decrease in ERα protein level in the MCF7 cell line in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SET7-IN-DC21 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF7 cells, HUV-EC-C cells, MRC-5 cells
Concentration: 0.5 μM, 1 μM, 1.5 μM, 2 μM, 2.5 μM
Incubation Time: 72 h
Result: Inhibited the proliferation of MCF7 cells in a dose-dependent manner (IC50 = 25.84 μM), and had little effect on the proliferation of normal cells, including normal embryonic lung fibroblast cell line MRC-5 and umbilical vascular endothelial cell line HUV-EC-C.

Cell Viability Assay[1]

Cell Line: MCF7 cells
Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM, 200 μM
Incubation Time: 72 h
Result: Dose-dependently reduced the protein expression level of estrogen receptor α (ERα) in MCF7 cells.
Molecular Weight

232.19

Formula

C12H8O5
CAS No.
SMILES

O=C(C=C1)C(C2=CC=C(C(OC)=O)O2)=CC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SET7-IN-DC21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SET7-IN-DC212567886-53-5Histone MethyltransferaseHistone methylationMolecular probeSET7Small-molecule inhibitorVirtual screeningInhibitorinhibitorinhibit

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