Diclofenac amide
Based on 1 Customer Validation
Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg).
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- CAS. Nr.: 15362-40-0
- Formel: C14H9Cl2NO
- Molecular Weight:278.14
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-Z6135
Aceclofenac impurity 3Drug Impurity -
HY-114689
Diclofenac methyl esterDiclofenac Metabolite -
HY-N7108
7-HydroxyflavoneAnti-inflammatory Agent -
HY-B0634
AceclofenacNSAID -
HY-120824
MofezolacCOX-1 Inhibitor -
HY-119469
Aceclofenac ethyl esterAceclofenac Impurity -
HY-41945
2,6-Dichloro-4-iodopyridineBiochemical Reagent -
HY-133976
Aceclofenac methyl esterAceclofenac Impurity -
HY-12085S
Apremilast-d5PDE-4 Inhibitor -
HY-Y0370
6-ChlorooxindoleChymase Inhibitor -
HY-W077257
5-Bromo-DL-tryptophanNatural product -
HY-B0634R
Aceclofenac (Standard)NSAID
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| B16-F10 | ED50 |
>100 μg/mL
Compound: 4a
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Cytotoxicity against Homo sapiens (human) B16F10 cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) B16F10 cells after 72 hr by MTT assay
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10.1007/s00044-012-0309-2 |
| HuTu80 | ED50 |
>100 μg/mL
Compound: 4a
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Cytotoxicity against Homo sapiens (human) HuTu 80 cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) HuTu 80 cells after 72 hr by MTT assay
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10.1007/s00044-012-0309-2 |
| KB | ED50 |
100 μg/mL
Compound: 4a
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Cytotoxicity against Homo sapiens (human) KB cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) KB cells after 72 hr by MTT assay
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10.1007/s00044-012-0309-2 |
| L132 | ED50 |
>100 μg/mL
Compound: 4a
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Cytotoxicity against Homo sapiens (human) L-132 cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) L-132 cells after 72 hr by MTT assay
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10.1007/s00044-012-0309-2 |
| MCF7 | ED50 |
>100 μg/mL
Compound: 4a
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Cytotoxicity against Homo sapiens (human) MCF7 cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) MCF7 cells after 72 hr by MTT assay
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10.1007/s00044-012-0309-2 |
| MIA PaCa-2 | ED50 |
>100 μg/mL
Compound: 4a
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Cytotoxicity against Homo sapiens (human) MIAPaCa2 cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) MIAPaCa2 cells after 72 hr by MTT assay
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10.1007/s00044-012-0309-2 |
| SW-620 | ED50 |
>100 μg/mL
Compound: 4a
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Cytotoxicity against human SW620 cells after 3 days by MTT assay
Cytotoxicity against human SW620 cells after 3 days by MTT assay
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[PMID: 18316139] |
Chemical Information
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CAS. Nr. 15362-40-0
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Appearance Solid
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Molecular Weight 278.14
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Formel C14H9Cl2NO
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SMILES
O=C1N(C2=C(Cl)C=CC=C2Cl)C3=C(C=CC=C3)C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Diclofenac amide Related Classifications
HY-134521 Related Classifications
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