15362-40-0
15362-40-0
Chemical Structure
Diclofenac amide
- CAS No.: 15362-40-0
- Formula:C14H9Cl2NO
- Molecular Weight:278.14
IUPAC Name: 1-(2,6-dichlorophenyl)indolin-2-one
InChIKey: JCICIFOYVSPMHG-UHFFFAOYSA-N
SMILES: O=C1N(C2=C(Cl)C=CC=C2Cl)C3=C(C=CC=C3)C1
Biological Activity: Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg)[1].
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Diclofenac amide | Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg). | |||||||||||||||||||||
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Aceclofenac impurity 3 | Aceclofenac impurity 3 is an impurity of Aceclofenac. | |||||||||||||||||||||
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Diclofenac Amide-13C6 | Diclofenac Amide-13C6 is the 13C-labeled Diclofenac amide (HY-134521). Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg). | |||||||||||||||||||||
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References
