Sunifiram (Synonyms: DM-235)

Art. -Nr.: HY-17550 Reinheit: 99.87%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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Sunifiram (DM-235) is an ampakine-like compound and an agonist of AMPA receptor with oral activity. Sunifiram can increase the release of acetylcholine in the rat cerebral cortex and exhibits potent cognitive enhancement effects with better nootropic activity compared to piracetam (HY-B0585). Sunifiram is promising for research in neurodegenerative diseases such as mild cognitive impairment (MCI) and Alzheimer's disease (AD).

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Sunifiram Chemische Struktur

CAS. Nr. : 314728-85-3

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5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
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This product is a controlled substance and not for sale in your territory.

Other Forms of Sunifiram:

Sunifiram (Standard) Angebot einholen

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle iGluR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

AMPA Receptor NMDA Receptor Kainate Receptor

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

In Vitro

Sunifiram (0.01-1 μM, 30 minutes) reduced the antagonistic effect of kynurenic acid on NMDA and increased NMDA activity^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	Rat hippocampal cells
Concentration:	0.01-1 μM
Incubation Time:	30 min
Result:	Decreased the antagonistic effect of kynurenic acid on NMDA (HY-17551)-induced tritium release in a concentration-dependent manner.

In Vivo

Sunifiram (0.001-0.1 mg/kg, p.o. or i.v., single dose, 20 minutes prior) is able to prevent amnesia in a scopolamine (HY-N0296)-induced amnesia mouse model^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Scopolamine-induced amnesia mice model^[4]
Dosage:	0.001-0.1 mg/kg
Administration:	Oral gavage (p.o.), Intraperitoneal injection (i.p.)
Result:	Prevented amnesia in a scopolamine-induced amnesia mouse model, with minimal effective doses of 0.001 mg/kg (i.p.) and 0.01 mg/kg (p.o.). Exhibited an antiamnesic effect comparable to that of well-known cognitive enhancers such as piracetam (HY-B0585) (30 mg/kg i.p.), aniracetam (HY-10932) (100 mg/kg p.o.), and rolipram (HY-16900) (30 mg/kg p.o.), but with a potency 1000 to 10000 times higher.

Molekulargewicht

246.30

Formel

C₁₄H₁₈N₂O₂

CAS. Nr.

314728-85-3

Appearance

Solid

Color

White to off-white

SMILES

CCC(N1CCN(C(C2=CC=CC=C2)=O)CC1)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 50 mg/mL (203.00 mM; Need ultrasonic)

DMSO : ≥ 2.6 mg/mL (10.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0601 mL	20.3004 mL	40.6009 mL
5 mM	0.8120 mL	4.0601 mL	8.1202 mL
10 mM	0.4060 mL	2.0300 mL	4.0601 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (203.00 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.87%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (246 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Galeotti N, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):538-45. [Content Brief]

[2]. Moriguchi S, et al. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Jun 3. [Content Brief]

[3]. Moriguchi S, et al. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1;242:150-7. [Content Brief]

[4]. Romanelli M N, et al. Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers[J]. CNS Drug Reviews, 2006, 12(1): 39-52. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.0601 mL	20.3004 mL	40.6009 mL	101.5022 mL
	5 mM	0.8120 mL	4.0601 mL	8.1202 mL	20.3004 mL
	10 mM	0.4060 mL	2.0300 mL	4.0601 mL	10.1502 mL
H₂O	15 mM	0.2707 mL	1.3534 mL	2.7067 mL	6.7668 mL
	20 mM	0.2030 mL	1.0150 mL	2.0300 mL	5.0751 mL
	25 mM	0.1624 mL	0.8120 mL	1.6240 mL	4.0601 mL
	30 mM	0.1353 mL	0.6767 mL	1.3534 mL	3.3834 mL
	40 mM	0.1015 mL	0.5075 mL	1.0150 mL	2.5376 mL
	50 mM	0.0812 mL	0.4060 mL	0.8120 mL	2.0300 mL
	60 mM	0.0677 mL	0.3383 mL	0.6767 mL	1.6917 mL
	80 mM	0.0508 mL	0.2538 mL	0.5075 mL	1.2688 mL
	100 mM	0.0406 mL	0.2030 mL	0.4060 mL	1.0150 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sunifiram Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sunifiram314728-85-3DM-235DM235DM 235iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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