2. Signaling Pathways
  3. Anti-infection
  4. Bacterial

Bacterial

Bacterial

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Anything that destroys bacteria or suppresses their growth or their ability to reproduce. Heat, chemicals such as chlorine, and antibiotic drugs all have antibacterial properties. Many antibacterial products for cleaning and handwashing are sold today. Such products do not reduce the risk for symptoms of viral infectious diseases in otherwise healthy persons. This does not preclude the potential contribution of antibacterial products to reducing symptoms of bacterial diseases in the home.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P5687
    Im5
    		Inhibitor
    Im5, an antimicrobial peptide, has antibacterial (MIC: 10, 2.5-5, 0.5-1 μM for E. coli, S. aureus, B. subtilis respectively) and hemolytic activity (EC50: 28 μM).
    Im5
  • HY-U00035R
    MGB-BP-3 (Standard)
    		Inhibitor
    Sinapine (thiocyanate) (Standard) is the analytical standard of Sinapine (thiocyanate). This product is intended for research and analytical applications. Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.
    MGB-BP-3 (Standard)
  • HY-19128
    CI-990
    		Inhibitor
    CI-990 (PD-131112) is an orally active and highly selective bacterial DNA gyrase inhibitor. CI-990 is promising for research of Enterococcal infections (e.g., endocarditis, sepsis).
    CI-990
  • HY-168511
    DNA Gyrase-IN-13
    		Inhibitor
    DNA Gyrase-IN-13 (compound 1b) is a DNA Gyrase inhibitor. DNA Gyrase-IN-13 has antibacterial activity. DNA Gyrase-IN-13 has an IC50 value of 1.81 μM for Staphylococcus aureus DNA gyrase.
    DNA Gyrase-IN-13
  • HY-W154247
    IP6C
    		Inhibitor
    IP6C is a specific inhibitor and phage sensitizer targeting type II Thoeris systems. IP6C competitively binds to histidine in the catalytic pocket of ThsB, blocks the production of the His-ADPR alarm signal and inhibits ThsA activation, thereby relieving bacterial stasis of phage replication. IP6C selectively resensitizes drug-resistant bacteria carrying type II Thoeris systems (such as Pseudomonas aeruginosa) to phage lysis, without affecting other bacteria, and shows no toxicity to mice and human cell lines. IP6C significantly improves the survival rate of infected mice, and can be used to overcome bacterial phage defense mechanisms and study Pseudomonas aeruginosa infections.
    Thoeris system: (named after the Egyptian goddess of fertility and protection), is a widespread anti-phage immune defense system in bacteria and archaea. Thoeris system belongs to the "Abortion Infection (Abi)" mechanism of bacteria: when an individual bacterium detects phage invasion, it initiates a suicide program and dies, thereby blocking phage replication and spread, and protecting the surrounding bacterial population from infection.
    IP6C
  • HY-155546
    Antimicrobial agent-22
    		Inhibitor
    Antimicrobial agent-22 (THI 6c) is a multi-target broad-spectrum antibacterial agent. Antimicrobial agent-22 has low cytotoxicity, hemolytic property, rapid bactericidal ability and good anti-biofilm activity.
    Antimicrobial agent-22
  • HY-P5685
    Maximin 49
    		Inhibitor
    Maximin 49 is an antimicrobial peptide. Maximin 49 has antibacterial activity against S. aureus (MIC: 18.8 μg/mL). Maximin 49 has hemolytic activities against human and rabbit red cells.
    Maximin 49
  • HY-125620
    Rubiginone D2
    		Inhibitor
    Rubiginone D2 is an antibiotic, which exhibits antimicrobial activities against Bacillus subtilis, Staphylococcus aureus and Escherichia coli. Rubiginone D2 exhibits antitumor efficacy, inhibits proliferations of cancer cells HM02, Kato III, HepG2 and MCF7, with GI50s of 0.1, 0.7, <0.1 and 7.5 μM, respectively.
    Rubiginone D2
  • HY-149810
    AcrB-IN-2
    		Inhibitor
    AcrB-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. AcrB-IN-22 inhibits Nile Red (a known substrate of AcrB) efflux.AcrB-IN-2 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model.
    AcrB-IN-2
  • HY-116039
    Epiroprim
    		Inhibitor
    Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor. Epiroprim displays excellent activity against staphylococci, enterococci, pneumococci, and streptococci.
    Epiroprim
  • HY-111396
    PC58538
    		Inhibitor
    PC58538 is a cell division inhibitor, targeting to FtsZ. PC58538 shows moderate antibacterial activity, and inhibits cell division in vegetative cells of wild-type B. subtilis. PC58538 is also known to modulate the rate of GTP hydrolysis.
    PC58538
  • HY-182496
    Kanchanamycin A
    		Inhibitor
    Kanchanamycin A is a 36-membered polyol macrolide antibiotic found in Streptomyces olivaceus Tü 4018, with high activity against Pseudomonas fluorescens, weak activity against Gram-positive bacteria and filamentous fungi, and no activity against yeasts. Kanchanamycin A inhibits growth of Pseudomonas fluorescens, Botrytis cinerea, Mucor miehei, Penicillium notatum, and Staphylococcus aureus. Kanchanamycin A is commonly used in the study of bacterial infections.
    Kanchanamycin A
  • HY-N4052A
    (±)-Heraclenol
    		Inhibitor
    (±)-Heraclenol, a coumarin, is isolated from the fruits of Angelica lucida, and exhibits antibacterial activities.
    (±)-Heraclenol
  • HY-N1160
    Tetrahydroxysqualene
    		Inhibitor
    Tetrahydroxysqualene is a triterpene, possessing antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 10.0 μg/mL. Tetrahydroxysqualene can be isolated from the methanolic extracts of Rhus taitensis Guill.
    Tetrahydroxysqualene
  • HY-105374
    PNU 101099
    		Inhibitor
    PNU 101099 is a 50S ribosomal subunit inhibitor. PNU 101099 has antibacterial activity. PNU 101099 can be used for infection research.
    PNU 101099
  • HY-169105
    DNA Gyrase-IN-12
    		Inhibitor
    DNA Gyrase-IN-12 (Compound 6d) is a DNA gyrase inhibitor. DNA Gyrase-IN-12 has Antibacterial activity and MIC value of vancomycin-intermediate S. aureus (VISA) and Enterococcus faecalis strains is between 0.031 and 0.0625 μg/mL.
    DNA Gyrase-IN-12
  • HY-P2202
    Desferriferribactin
    Desferriferribactin is a cyclic peptide containing a thirteen-membered ring. Desferriferribactin is a precursor of pyoverdins.
    Desferriferribactin
  • HY-P11396
    Metalnikowin I
    		Inhibitor
    Metalnikowin I (MetI) is a proline-rich antimicrobial peptide and DnaK inhibitor. Metalnikowin I can be derived from insects.
    Metalnikowin I
  • HY-149395
    MmpL3-IN-3
    		Inhibitor
    MmpL3-IN-3 (Compound 12) is a MmpL3 inhibitor. MmpL3-IN-3 shows a MIC of 0.1 μM against H37Rv. MmpL3-IN-3 shows good stability in mouse liver microsomes. MmpL3-IN-3 can be used for anti-tubercular research.
    MmpL3-IN-3
  • HY-146652
    UGM-IN-3
    		Inhibitor
    UGM-IN-3 (compound 10a) is a UDP-galactopyranose mutase (UGM) inhibitor with a Kd of 66 μM. UGM-IN-3 inhibits the growth of Mycobacterium tuberculosis with a MIC value of 6.2 μg/mL.
    UGM-IN-3
Cat. No. Product Name / Synonyms Application Reactivity