AcrB-IN-2
AcrB-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics. AcrB-IN-22 inhibits Nile Red (a known substrate of AcrB) efflux.AcrB-IN-2 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model.
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- CAS No.: 2890177-90-7
- 화학식: C30H35NO6
- 분자량:505.60
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
AcrB-IN-2 (compound G6) (8-128 μg/mL) shows outstanding antibacterial synergism with at least one of the antibiotics (ERY, LEV and MIN). AcrB-IN-2 show antibacterial synergism with MIN, and reduces the MIC value of MIN by 4-fold at 64 μg/mL[1].
AcrB-IN-2 (50 μM, 100 μM) shows strong inhibitory activity at the lowest concentration of 50 μM, to inhibit Nile Red efflux[1].
AcrB-IN-2 (4-256 μg/mL) does not cause hemolysis of mice red blood cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2890177-90-7
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분자량 505.60
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화학식 C30H35NO6
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SMILES
COC1=CC=C(C=C1)OCCCOC2=CC=CC3=C2C=C(C4=C3OC(C)(CC4)C)C(N5CCOCC5)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AcrB-IN-2 Related Classifications
HY-149810 Related Classifications
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