2. Signaling Pathways
  3. Immunology/Inflammation
  4. COX

COX

Cyclooxygenase

COX

Related Products

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Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX Isoform Specific Products:

COX Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0894R
    Octahydrocurcumin (Standard)
    		Inhibitor
    Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is a hydrogenated derivative of curcumin and a metabolite of curcumin. Octahydrocurcumin is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively.
    Octahydrocurcumin (Standard)
  • HY-N0589R
    Dehydrodiisoeugenol (Standard)
    		Inhibitor
    Dehydrodiisoeugenol (Standard) is the analytical standard of Dehydrodiisoeugenol (HY-N0589). This product is intended for research and analytical applications. Dehydrodiisoeugenol is an orally active anti-inflammatory and anti-tumor agent. Dehydrodiisoeugenol inhibits the proliferation of colorectal cancer cells, and induces apoptosis, autophagy, endoplasmic reticulum stress and cell cycle arrest. Dehydrodiisoeugenol also exerts anti-inflammatory effects by inhibiting the activation of NF-κB and the expression of COX-2. Dehydrodiisoeugenol can be used in the research related to colorectal cancer, inflammatory diseases and ulcerative colitis.
    Dehydrodiisoeugenol (Standard)
  • HY-118691
    BMS-347070
    		Inhibitor
    BMS-347070 is an inhibitor of COX-2. BMS-347070 can be studied in research on Pluronic®-bassed nano-crystalline drug-polymer solid dispersions.
    BMS-347070
  • HY-B1799R
    Tolmetin (Standard)
    		Inhibitor
    Tolmetin (Standard) is the analytical standard of Tolmetin. This product is intended for research and analytical applications. Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID).
    Tolmetin (Standard)
  • HY-59105R
    SC-560 (Standard)
    		Inhibitor
    SC-560 (Standard) is the analytical standard of SC-560. This product is intended for research and analytical applications. SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM.
    SC-560 (Standard)
  • HY-78131CR
    Ibuprofen sodium (Standard)
    		Inhibitor
    Ibuprofen (sodium) (Standard) is the analytical standard of Ibuprofen (sodium). This product is intended for research and analytical applications. Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers.
    Ibuprofen sodium (Standard)
  • HY-N7324
    Dehydroperilloxin
    		Inhibitor
    Dehydroperilloxin is a natural compound isolated from the dichloromethane extract of the stems of Perilla frutescens var. acuta. Dehydroperilloxin possesses inhibitory activity against cyclooxygenase-1, with the IC50 value of 30.4 μM.
    Dehydroperilloxin
  • HY-U00013R
    Nitroflurbiprofen (Standard)
    		Inhibitor
    Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
    Nitroflurbiprofen (Standard)
  • HY-19384R
    Enflicoxib (Standard)
    		Inhibitor
    Enflicoxib (Standard) is the analytical standard of Enflicoxib. This product is intended for research and analytical applications. Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models.
    Enflicoxib (Standard)
  • HY-107632G
    GYY4137 (GMP)
    		Inhibitor
    GYY4137 (GMP) is the GMP-grade version of GYY4137 (HY-107632). Small molecules of GMP grade can be used as adjuvant reagents in cell therapy. GYY4137 (GMP) is a sustained-release H2S donor possessing vasodilatory, antihypertensive, and anti-inflammatory activities. GYY4137 (GMP) can inhibit cell growth, induce apoptosis, and cause cell cycle arrest by blocking the STAT3 pathway, demonstrating potent anticancer activity.
    GYY4137 (GMP)
  • HY-119878
    Lobuprofen
    		Inhibitor
    Lobuprofen is a potent COX inhibitor. Lobuprofen can be used in study neurological diseases.
    Lobuprofen
  • HY-W010037R
    2-(tert-Butyl)-4-methoxyphenol (Standard)
    		Inhibitor
    2-(tert-Butyl)-4-methoxyphenol (Standard) is the analytical standard of 2-(tert-Butyl)-4-methoxyphenol. This product is intended for research and analytical applications. 2-tert-Butyl-4-methoxyphenol is a major component of Butylhydroxyanisole (BHA) (HY-B1066). 2-tert-Butyl-4-methoxyphenol is an antioxidant agent, that inhibits expression of Cox2 and Tnfa genes upon stimulation with Lipopolysaccharides (HY-D1056). 2-tert-Butyl-4-methoxyphenol exhibits anti-inflammatory activity, combined with 2,6-di-tert-butyl-4-methylphenol (BHT).
    2-(tert-Butyl)-4-methoxyphenol (Standard)
  • HY-N6663R
    3-Carene (Standard)
    		Inhibitor
    3-Carene (Standard) is the analytical standard of 3-Carene. This product is intended for research and analytical applications. 3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation.
    3-Carene (Standard)
  • HY-B1221R
    Flufenamic acid (Standard)
    		Inhibitor
    Flufenamic acid (Standard) is the analytical standard of Flufenamic acid. This product is intended for research and analytical applications. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
    Flufenamic acid (Standard)
  • HY-B1026R
    Adelmidrol (Standard)
    		Inhibitor
    Adelmidrol (Standard) is the analytical standard of Adelmidrol. This product is intended for research and analytical applications. Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces NF-κB translocation, and COX-2 expression.
    Adelmidrol (Standard)
  • HY-105142
    M-5011
    		Inhibitor
    M-5011 is a potent and orally active anti-inflammatory agent. M-5011 shows potent antinociceptive effects and inhibits kaolin (HY-W115786)-induced writhing. M-5011 decreases peritoneal 6-keto-PGF1 alpha levels with low ulcerogenic activities. M-5011 shows anti-inflammatory and anti-pyretic effects and analgesic effect.
    M-5011
  • HY-B2137R
    S-(+)-Ketoprofen (Standard)
    		Inhibitor
    S-(+)-Ketoprofen (Standard) is the analytical standard of S-(+)-Ketoprofen. This product is intended for research and analytical applications. S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
    S-(+)-Ketoprofen (Standard)
  • HY-W013164R
    SC-58125 (Standard)
    		Inhibitor
    SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2), with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo. SC-58125 also can inhibit edema at the inflammatory site and has analgesic effect.
    SC-58125 (Standard)
  • HY-B0580S1
    Ketorolac-d4
    		Inhibitor
    Ketorolac-d4 (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
    Ketorolac-d<sub>4</sub>
  • HY-A0273R
    Propyphenazone (Standard)
    		Inhibitor
    Propyphenazone (Standard) is the analytical standard of Propyphenazone. This product is intended for research and analytical applications. Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity.
    Propyphenazone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
COX Isoform Comparison

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