1. Signaling Pathways
  2. Apoptosis
  3. Caspase
  4. Caspase Isoform
  5. Caspase Activator

Caspase Activator

Caspase Activators (21):

Cat. No. Product Name Effect Purity
  • HY-107738
    Guggulsterone
    Activator 99.83%
    Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii.
  • HY-136241
    OT-82
    Activator 99.84%
    OT-82 is a potent, selective and orally active inhibitor of NAMPT.
  • HY-13560
    AVN-944
    Activator 99.56%
    AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase).
  • HY-15586
    L67
    Activator ≥98.0%
    L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC50 are 10 μM).
  • HY-13721
    Phenoxodiol
    Activator 99.76%
    Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis.
  • HY-N6843
    Arnicolide D
    Activator 99.20%
    Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima.
  • HY-119272
    EF24
    Activator 99.78%
    EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC).
  • HY-W042191
    Oxychlororaphine
    Activator
    Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil.
  • HY-101287
    MPT0B392
    Activator ≥99.0%
    MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis.
  • HY-N6801
    Nivalenol
    Activator ≥99.0%
    Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product.
  • HY-N6681
    15-Acetoxyscirpenol
    Activator 99.35%
    15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3.
  • HY-118304
    AKN-028
    Activator
    AKN-028, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM.
  • HY-B1193S1
    Terfenadine-d10
    Activator
  • HY-122928
    Rosamultic acid
    Activator
    Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora.
  • HY-17495
    Carteolol
    Activator
    Carteolol is a non-selective β-adrenoceptor antagonist.
  • HY-150696
    Antitumor agent-72
    Activator
    Antitumor agent-72 (compound 6w) is a potent anticancer agent.
  • HY-N4238
    Dehydrocorydaline nitrate
    Activator 99.89%
    Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid.
  • HY-146444
    Anticancer agent 56
    Activator
    Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with drug-likeness properties, possessing anticancer activity against several cancer cell lines (IC50<3 μM).
  • HY-146461
    Anticancer agent 58
    Activator
    Anticancer agent 58 (compound 16) has inhibitory activity against kinds of cancer cell lines, especially in A549 and T24 with IC50s of 0.6 μM and 0.7 μM, respectively.
  • HY-118304B
    AKN-028 acetate
    Activator 99.95%
    AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM.