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Cat. No.: HY-17495

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Carteolol

Name: Carteolol
Brand: MedChemExpress
SKU: HY-17495
Availability: PreOrder

(Synonyms: OPC-1085)

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 51781-06-7
화학식: C₁₆H₂₄N₂O₃
분자량:292.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Carteolol Chemical Structure

CAS No.: 51781-06-7

사이즈

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재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Clinical Trial
Chemical Information
Publications (2)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research^[1].

All Adrenergic Receptor Isoforms :

All Caspase Isoforms :

All Bcl-2 Family Isoforms :

In Vitro

Carteolol (0-2%; 0-28 hours; HCECs) has cytotoxicity and decreases cell viability in a dose- and time-dependent manner^[1].
Carteolol (0.25%; 4-12 hours; HCECs) induces apoptosis and necroptotic protein expression in HCECs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HCECs
Concentration:

0.00390625-2%
Incubation Time:

0, 2, 4, 8, 16, 20,24 and 28 hours
Result:

Decreased cell viability with the concentrations above 0.0015625% in a dose- and time-dependent manner.

Western Blot Analysis^[1]

Cell Line:

HCECs
Concentration:

0.25%
Incubation Time:

4, 8 and 12 hours
Result:

Dampened expression of the anti-apoptotic protein Bcl-2 and Bcl-xL, enhanced expression of the pro-apoptotic proteins Bax and Bad, and mitochondrial-released pro-apoptotic proteins Cyt.c and AIF.

Cell Cycle Analysis^[1]

Cell Line:

HCECs
Concentration:

0.25%
Incubation Time:

4, 8 and 12 hours
Result:

Increased the number of G1 phase of the cell cycle, whereas decreased S phase.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 51781-06-7
분자량 292.37
화학식 C₁₆H₂₄N₂O₃
SMILES

O=C1NC2=C(C(OCC(O)CNC(C)(C)C)=CC=C2)CC1
Synonyms

OPC-1085
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Sort by:

Journal Impact Factor

ACS Omega

Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors. [Abstract]

2022 Aug 8;7(32):27950-27958. PMID: 35983371
J Pharm Biomed Anal

Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]

2021 Feb 20:195:113870. PMID: 33453569

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Su W, et, al. Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms. Front Pharmacol. 2020 Mar 6;11:202. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Carteolol

2 Cited Publications

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Biological Activity
- 제품 설명
- In Vitro
- Clinical Trial
Chemical Information
Publications (2)
순도&문서
References

상품명:
Cat. No.:
수량:
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Carteolol

Publications Citing Use of MedChemExpress (MCE) Carteolol

All Adrenergic Receptor Isoforms

All Caspase Isoforms

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Publications (2)

순도&문서

References

Calculators

Help & FAQs

Carteolol Related Classifications

HY-17495 Related Classifications

Bioz