1. Apoptosis
    Cell Cycle/DNA Damage
  2. Caspase
    Apoptosis
    Topoisomerase
  3. Phenoxodiol

Phenoxodiol (Synonyms: Idronoxil; Dehydroequol; Haginin E)

Cat. No.: HY-13721 Purity: >98.0%
Handling Instructions

Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner.

For research use only. We do not sell to patients.

Phenoxodiol Chemical Structure

Phenoxodiol Chemical Structure

CAS No. : 81267-65-4

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Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2].

IC50 & Target

Caspase, DNA topoisomerase II[1][2].

Clinical Trial
Molecular Weight

240.25

Formula

C₁₅H₁₂O₃

CAS No.

81267-65-4

SMILES

OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Phenoxodiol
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HY-13721
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