2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Dopamine Receptor
  5. Dopamine Receptor Isoform
  6. Dopamine Receptor Antagonist

Dopamine Receptor Antagonist

Dopamine Receptor Antagonists (81):

Cat. No. Product Name Effect Purity
  • HY-17366
    Clozapine N-oxide
    		Antagonist 99.98%
    Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist.
  • HY-17366A
    Clozapine N-oxide dihydrochloride
    		Antagonist 98.17%
    Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist.
  • HY-14538
    Haloperidol
    		Antagonist 99.65%
    Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
  • HY-14541
    Olanzapine
    		Antagonist 99.83%
    Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM).
  • HY-B1019
    Sulpiride
    		Antagonist 99.92%
    Sulpiride is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class, used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression.
  • HY-135147
    ONC206
    		Antagonist 99.90%
    ONC206 is an analogue of TRAIL inducer ONC201.
  • HY-B1693
    Levomepromazine
    		Antagonist 99.98%
    Levomepromazine (Methotrimeprazine) is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings.
  • HY-101348
    L-741626
    		Antagonist ≥99.0%
    L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively.
  • HY-N0925
    Tetrahydroberberine
    		Antagonist 99.65%
    Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).
  • HY-14545
    Amisulpride
    		Antagonist 99.92%
    Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
  • HY-B1371
    Spiperone
    		Antagonist
    Spiperone is a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist.
  • HY-A0163
    Zuclopenthixol
    		Antagonist 98.13%
    Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist.
  • HY-42849A
    Sultopride hydrochloride
    		Antagonist 99.27%
    Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective antagonist of dopamine D2 receptor.
  • HY-B1613A
    Clebopride malate
    		Antagonist 99.77%
    Clebopride malate is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders.
  • HY-B1240
    Droperidol
    		Antagonist 99.29%
    Droperidol is a Dopamine-2 Receptor Antagonist.
  • HY-19654
    GSK598809
    		Antagonist 99.73%
    GSK598809 is a potent and selective dopamine D3 Receptor (DRD3) antagonist, with a pKi of 8.9.
  • HY-B1470
    Azaperone
    		Antagonist 99.77%
    Azaperone (R-1929) acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties.
  • HY-B1059
    Levosulpiride
    		Antagonist 99.88%
    Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class.
  • HY-19489S
    (±)-Levomepromazine-d6
    		Antagonist ≥98.0%
    (±)-Levomepromazine D6 ((±)-Methotrimeprazine D6) is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.
  • HY-129946
    Dopamine D2 receptor antagonist-1
    		Antagonist 99.05%
    Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity.