Cat. No.: HY-W344044

Levomepromazine maleate

(Synonyms: Methotrimeprazine maleate)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Levomepromazine maleate (Methotrimeprazine maleate) is an orally active antipsychotic compound and Ca²⁺ release inducer. Levomepromazine maleate inhibits SERCA pump and induces an increase in cytoplasmic Ca²⁺ levels. Levomepromazine maleate has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine maleate can induce adaptive ER stress and autophagy. In addition, Levomepromazine maleate has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine maleate can be used in the study psychiatric disorders and relieving nausea and vomiting.

For research use only. We do not sell to patients.

Purity: 99.92%
CAS No.: 7104-38-3
Formula: C₂₃H₂₈N₂O₅S
Molecular Weight:444.54

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Levomepromazine maleate Chemical Structure

CAS No.: 7104-38-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All 5-HT Receptor Isoforms :

All Dopamine Receptor Isoforms :

All Histamine Receptor Isoforms :

All Calcium Channel Isoforms :

In Vitro

Levomepromazine (10 μM; 24 h) maleate reduces Japanese encephalitis virus (JEV)-induced Neuro2a cell death, reduces JEV RNA levels and viral titers, and significantly inhibits JEV protein translation/replication complex formation and ROS production^[1].
Levomepromazine (10 μM; 24 h) maleate decreases the inflammatory response of microglia by inducing autophagy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

Japanese encephalitis virus treated Neuro2a
Concentration:

10 μM
Incubation Time:

24 h
Result:

Reduced the level of JEV RNA.

In Vivo

Levomepromazine (2 mg/kg; oral gavage; 15 days) maleate has antiviral and anti-inflammatory activity in a mouse model infected with Japanese encephalitis virus^[1].
Levomepromazine (5-20 mg/kg; intraperitoneal injection; single dose) maleate has analgesic, sedative and anti-injurious effects in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Japanese encephalitis virus-S3 infected C57BL/6 mouse^[1]
Dosage:

2 mg/kg
Administration:

Oral gavage (i.g.); 15 days
Result:

Delayed virus invasion into the brain, and significantly lower viremia.
Showed complete protection of the barrier.
Reduced levels of multiple pro-inflammatory cytokines and interferon in the brains of infected mice.

Chemical Information

CAS No. 7104-38-3
Appearance Solid
Molecular Weight 444.54
Formula C₂₃H₂₈N₂O₅S
Color White to off-white
SMILES

CN(C)C[C@@H](C)CN1C2=CC(OC)=CC=C2SC3=CC=CC=C31.OC(/C=C\C(O)=O)=O
Synonyms

Methotrimeprazine maleate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Br J Pharmacol

Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABAA receptors by two distinct mechanisms. [Abstract]

2022 Jul;179(14):3675-3692. PMID: 35088415

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (112.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2495 mL

11.2476 mL

22.4952 mL

5 mM

0.4499 mL

2.2495 mL

4.4990 mL

10 mM

0.2250 mL

1.1248 mL

2.2495 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Prajapat SK, et al. Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy. EMBO Mol Med. 2024 Jan;16(1):185-217. [Content Brief]

[2]. Petts HV, et al. Interactions of morphine and methotrimeprazine in mouse and man with respect to analgesia, respiration and sedation. Br J Anaesth. 1983 May;55(5):437-41. [Content Brief]

[3]. Cox L, et al. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database Syst Rev. 2015 Nov 2;(11):CD009420. [Content Brief]

[4]. Sivaraman P, et al. Levomepromazine for schizophrenia. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD007779. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2495 mL	11.2476 mL	22.4952 mL	56.2379 mL
	5 mM	0.4499 mL	2.2495 mL	4.4990 mL	11.2476 mL
	10 mM	0.2250 mL	1.1248 mL	2.2495 mL	5.6238 mL
	15 mM	0.1500 mL	0.7498 mL	1.4997 mL	3.7492 mL
	20 mM	0.1125 mL	0.5624 mL	1.1248 mL	2.8119 mL
	25 mM	0.0900 mL	0.4499 mL	0.8998 mL	2.2495 mL
	30 mM	0.0750 mL	0.3749 mL	0.7498 mL	1.8746 mL
	40 mM	0.0562 mL	0.2812 mL	0.5624 mL	1.4059 mL
	50 mM	0.0450 mL	0.2250 mL	0.4499 mL	1.1248 mL
	60 mM	0.0375 mL	0.1875 mL	0.3749 mL	0.9373 mL
	80 mM	0.0281 mL	0.1406 mL	0.2812 mL	0.7030 mL
	100 mM	0.0225 mL	0.1125 mL	0.2250 mL	0.5624 mL

Keywords

Levomepromazine maleate

1 Cited Publications

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Levomepromazine maleate

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Publications Citing Use of MedChemExpress (MCE) Levomepromazine maleate

All 5-HT Receptor Isoforms

All Dopamine Receptor Isoforms

All Histamine Receptor Isoforms

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Levomepromazine maleate Related Classifications

HY-W344044 Related Classifications