7104-38-3
Chemical Structure
Levomepromazine maleate
Synonym(s): Methotrimeprazine maleate
- CAS No.: 7104-38-3
- Formula:C23H28N2O5S
- Molecular Weight:444.54
IUPAC Name: ethyl 5-amino-1-methyl-1H-indole-2-carboxylate
InChIKey: IFLZPECPTYCEBR-VIEYUMQNSA-N
SMILES: CN(C)C[C@@H](C)CN1C2=CC(OC)=CC=C2SC3=CC=CC=C31.OC(/C=C\C(O)=O)=O
Biological Activity: Levomepromazine maleate (Methotrimeprazine maleate) is an orally active antipsychotic compound and Ca2+ release inducer. Levomepromazine maleate inhibits SERCA pump and induces an increase in cytoplasmic Ca2+ levels. Levomepromazine maleate has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine maleate can induce adaptive ER stress and autophagy. In addition, Levomepromazine maleate has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine maleate can be used in the study psychiatric disorders and relieving nausea and vomiting[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Levomepromazine maleate | 99.92% | Levomepromazine maleate (Methotrimeprazine maleate) is an orally active antipsychotic compound and Ca2+ release inducer. Levomepromazine maleate inhibits SERCA pump and induces an increase in cytoplasmic Ca2+ levels. Levomepromazine maleate has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine maleate can induce adaptive ER stress and autophagy. In addition, Levomepromazine maleate has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine maleate can be used in the study psychiatric disorders and relieving nausea and vomiting. | ||||||||||||||||||||
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- [1]. Prajapat SK, et al. Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy. EMBO Mol Med. 2024 Jan;16(1):185-217. [Content Brief]
- [2]. Petts HV, et al. Interactions of morphine and methotrimeprazine in mouse and man with respect to analgesia, respiration and sedation. Br J Anaesth. 1983 May;55(5):437-41. [Content Brief]
- [3]. Cox L, et al. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database Syst Rev. 2015 Nov 2;(11):CD009420. [Content Brief]
- [4]. Sivaraman P, et al. Levomepromazine for schizophrenia. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD007779. [Content Brief]
Keywords
