Levomepromazine hydrochloride  (Synonyms: Methotrimeprazine hydrochloride)

Levomepromazine (Methotrimeprazine) hydrochloride is an orally active antipsychotic compound and Ca²⁺ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca²⁺ levels. Levomepromazine hydrochloride has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine hydrochloride can induce adaptive ER stress and autophagy. In addition, Levomepromazine hydrochloride has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine hydrochloride can be used in the study psychiatric disorders and relieving nausea and vomiting^[1][2][3][4].

Levomepromazine (10 μM; 24 h) hydrochloride reduces Japanese encephalitis virus (JEV)-induced Neuro2a cell death, reduces JEV RNA levels and viral titers, and significantly inhibits JEV protein translation/replication complex formation and ROS production^[1].
Levomepromazine (10 μM; 24 h) hydrochloride decreases the inflammatory response of microglia by inducing autophagy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Levomepromazine (2 mg/kg; oral gavage; 15 days) hydrochloride has antiviral and anti-inflammatory activity in a mouse model infected with Japanese encephalitis virus^[1].
Levomepromazine (5-20 mg/kg; intraperitoneal injection; single dose) hydrochloride has analgesic, sedative and anti-injurious effects in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

364.93

C₁₉H₂₅ClN₂OS

1236-99-3

CN(C)C[C@@H](C)CN1C2=CC(OC)=CC=C2SC3=CC=CC=C31.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Prajapat SK, et al. Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy. EMBO Mol Med. 2024 Jan;16(1):185-217.  [Content Brief]

  [2]. Petts HV, et al. Interactions of morphine and methotrimeprazine in mouse and man with respect to analgesia, respiration and sedation. Br J Anaesth. 1983 May;55(5):437-41.  [Content Brief]

  [3]. Cox L, et al. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database Syst Rev. 2015 Nov 2;(11):CD009420.  [Content Brief]

  [4]. Sivaraman P, et al. Levomepromazine for schizophrenia. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD007779.  [Content Brief]