Levomepromazine hydrochloride
Based on 1 publication(s) in Google Scholar
Levomepromazine (Methotrimeprazine) hydrochloride is an orally active antipsychotic compound and Ca2+ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca2+ levels. Levomepromazine hydrochloride has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine hydrochloride can induce adaptive ER stress and autophagy. In addition, Levomepromazine hydrochloride has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine hydrochloride can be used in the study psychiatric disorders and relieving nausea and vomiting.
For research use only. We do not sell to patients.
- CAS No.: 1236-99-3
- Formula: C19H25ClN2OS
- Molecular Weight:364.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Levomepromazine hydrochloride
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Biological Activity
Levomepromazine (10 μM; 24 h) hydrochloride reduces Japanese encephalitis virus (JEV)-induced Neuro2a cell death, reduces JEV RNA levels and viral titers, and significantly inhibits JEV protein translation/replication complex formation and ROS production[1].
Levomepromazine (10 μM; 24 h) hydrochloride decreases the inflammatory response of microglia by inducing autophagy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Japanese encephalitis virus treated Neuro2a
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Concentration:10 μM
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Incubation Time:24 h
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Result:Reduced the level of JEV RNA.
Levomepromazine (5-20 mg/kg; intraperitoneal injection; single dose) hydrochloride has analgesic, sedative and anti-injurious effects in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Japanese encephalitis virus-S3 infected C57BL/6 mouse[1]
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Dosage:2 mg/kg
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Administration:Oral gavage (i.g.); 15 days
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Result:Delayed virus invasion into the brain, and significantly lower viremia.
Showed complete protection of the barrier.
Reduced levels of multiple pro-inflammatory cytokines and interferon in the brains of infected mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1236-99-3
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Molecular Weight 364.93
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Formula C19H25ClN2OS
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SMILES
CN(C)C[C@@H](C)CN1C2=CC(OC)=CC=C2SC3=CC=CC=C31.Cl
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Synonyms
Methotrimeprazine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Br J Pharmacol
Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABAA receptors by two distinct mechanisms. [Abstract]2022 Jul;179(14):3675-3692. PMID: 35088415
Purity & Documentation
References
[1]. Prajapat SK, et al. Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy. EMBO Mol Med. 2024 Jan;16(1):185-217. [Content Brief]
[2]. Petts HV, et al. Interactions of morphine and methotrimeprazine in mouse and man with respect to analgesia, respiration and sedation. Br J Anaesth. 1983 May;55(5):437-41. [Content Brief]
[3]. Cox L, et al. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database Syst Rev. 2015 Nov 2;(11):CD009420. [Content Brief]
[4]. Sivaraman P, et al. Levomepromazine for schizophrenia. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD007779. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Levomepromazine hydrochloride Related Classifications
HY-B1693A Related Classifications
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