Acepromazine maleate
Based on 1 publication(s) in Google Scholar
Acepromazine (Acetopromazine) maleate is a phenothiazine tranquilizer and is alpha-adrenoceptor antagonist.
For research use only. We do not sell to patients.
- Purity: 99.40%
- CAS No.: 3598-37-6
- Formula: C23H26N2O5S
- Molecular Weight:442.53
-
Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Acepromazine maleate
MoreAll Adrenergic Receptor Isoforms
More
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3598-37-6
-
Appearance Solid
-
Molecular Weight 442.53
-
Formula C23H26N2O5S
-
Color Light yellow to yellow
-
SMILES
CC(C(C=C1N2CCCN(C)C)=CC=C1SC3=C2C=CC=C3)=O.O=C(O)/C=C\C(O)=O
-
Synonyms
Acetopromazine maleate; Acetylpromazine maleate
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Commun Biol
Anterior cingulate cortex mediates the comorbidity between colorectal cancer and depression-like behaviors. [Abstract]2025 Aug 27;8(1):1284. PMID: 40866718
Solvent & Solubility
DMSO : 100 mg/mL (225.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Gaulier JM, et al. Identification of acepromazine in hair: an illustration of the difficulties encountered in investigating drug-facilitated crimes. J Forensic Sci. 2008;53(3):755-759. [Content Brief]
[2]. Watney GC, et al. Effects of xylazine and acepromazine on bronchomotor tone of anaesthetised ponies. Equine Vet J. 1988;20(3):185-188. [Content Brief]
[3]. Harrigan T, et al. Prevention of sudden cardiac death by the atypical neuroleptic acepromazine following status epilepticus in rats. Life Sci. 1994;54(24):PL457-PL462. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2597 mL | 11.2987 mL | 22.5973 mL | 56.4933 mL |
| 5 mM | 0.4519 mL | 2.2597 mL | 4.5195 mL | 11.2987 mL | |
| 10 mM | 0.2260 mL | 1.1299 mL | 2.2597 mL | 5.6493 mL | |
| 15 mM | 0.1506 mL | 0.7532 mL | 1.5065 mL | 3.7662 mL | |
| 20 mM | 0.1130 mL | 0.5649 mL | 1.1299 mL | 2.8247 mL | |
| 25 mM | 0.0904 mL | 0.4519 mL | 0.9039 mL | 2.2597 mL | |
| 30 mM | 0.0753 mL | 0.3766 mL | 0.7532 mL | 1.8831 mL | |
| 40 mM | 0.0565 mL | 0.2825 mL | 0.5649 mL | 1.4123 mL | |
| 50 mM | 0.0452 mL | 0.2260 mL | 0.4519 mL | 1.1299 mL | |
| 60 mM | 0.0377 mL | 0.1883 mL | 0.3766 mL | 0.9416 mL | |
| 80 mM | 0.0282 mL | 0.1412 mL | 0.2825 mL | 0.7062 mL | |
| 100 mM | 0.0226 mL | 0.1130 mL | 0.2260 mL | 0.5649 mL |
Acepromazine maleate Related Classifications
HY-B1506A Related Classifications
Powered by Bioz