FGFR
Fibroblast growth factor receptor
FGFR (Fibroblast growth factor receptors) are the receptors that bind to members of the fibroblast growth factor family of proteins. Some of these receptors are involved in pathological conditions. A point mutation in FGFR3 can lead to achondroplasia. Five distinct membrane FGFR have been identified in vertebrates and all of them belong to the tyrosine kinase superfamily (FGFR1, FGFR2, FGFR3, FGFR4, FGFR6). The fibroblast growth factor family constitutes one of the most important groups of paracrine factors that act during development. They are responsible for determining certain cells to become mesoderm, for the production of blood vessels, for limb outgrowth, and for the growth and differentiation of numerous cell types.
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FGFR Inhibitors
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FGFR Agonists
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FGFR Antagonist
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FGFR Activators
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FGFR Modulators
(3)
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FGFR Degraders
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FGFR Control
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FGFR Ligand
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FGFR Proteins
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FGFR-1 Proteins
(20)
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FGFR-2 Proteins
(31)
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FGFR-3 Proteins
(26)
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FGFR-4 Proteins
(18)
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FGFR Related Products (383)
Related Products (383)
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Recombinant Proteins (97)
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Antibodies (11)
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Dovitinib (Standard)
0 ImagesSynonyms: CHIR-258 (Standard); TKI258 (Standard)Dovitinib (Standard) is the analytical standard of Dovitinib. This product is intended for research and analytical applications. Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC50s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, CSF-1R, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively. Dovitinib has potent antitumor activity.
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(Z)-Orantinib (Standard)
0 ImagesCat. No.: HY-10517ARCAS No.: 210644-62-5Synonyms: (Z)-SU6668 (Standard); (Z)-TSU-68 (Standard)(Z)-Orantinib (Standard) is the analytical standard of (Z)-Orantinib (HY-10517A). This product is intended for research and analytical applications. (Z)-Orantinib ((Z)-SU6668) is a potent, selective, orally active and ATP competitive inhibitor of Flk‐1/KDR, PDGFRβ, and FGFR1, with IC50s of 2.1, 0.008, and 1.2 μM, respectively. (Z)-Orantinib is a potent antiangiogenic and antitumor agent that induces regression of established tumors.
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α-Trinositol
0 ImagesCat. No.: HY-105279CAS No.: 28841-62-5Synonyms: PP 56α-Trinositol (PP 56) is an isomer of the intracellular messenger IP3. α-Trinositol can be used in the study of in vitro cytotoxicity and glutamate-induced glial cytotoxic swelling and injury.
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Anti-FGFR1/CD331 Antibody
0 ImagesCat. No.: HY-P990415The Anti-FGFR1/CD331 Antibody is a humanized antibody expressed in CHO cells, targeting FGFR1/CD331. The Anti-FGFR1/CD331 Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-FGFR1/CD331 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
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Nintedanib esylate (Standard)
0 ImagesSynonyms: BIBF 1120 esylate (Standard)Nintedanib esylate (Standard) is the analytical standard of Nintedanib esylate. This product is intended for research and analytical applications. Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
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Regorafenib (Standard)
0 ImagesSynonyms: BAY 73-4506 (Standard)Regorafenib (Standard) is the analytical standard of Regorafenib. This product is intended for research and analytical applications. Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib shows very robust antitumor and antiangiogenic activity.
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Infigratinib (Standard)
0 ImagesSynonyms: BGJ-398 (Standard); NVP-BGJ398 (Standard)Infigratinib (Standard) is the analytical standard of Infigratinib. This product is intended for research and analytical applications. Infigratinib (BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
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Infigratinib phosphate (Standard)
0 ImagesSynonyms: BGJ-398 phosphate (Standard); NVP-BGJ398 phosphate (Standard)Infigratinib phosphate (Standard) is the analytical standard of Infigratinib phosphate. This product is intended for research and analytical applications. Infigratinib phosphate (BGJ-398 phosphate; NVP-BGJ398 phosphate) is a potent inhibitor of the FGFR family with IC50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
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Pazopanib-d3
0 ImagesCat. No.: HY-10208S2CAS No.: 1219591-97-5Synonyms: GW786034-d3
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XL 999 (Standard)
0 ImagesCat. No.: HY-100315RCAS No.: 705946-27-6Synonyms: Tyrosine kinase-IN-1 (Standard)XL 999 (Standard) is the analytical standard of XL 999 (HY-100315). This product is intended for research and analytical applications. XL999 is a multi-target tyrosine kinase inhibitor. XL999 has IC50 values for KDR, Flt-1, FGFR1 and PDGFRα of 4 nM, 20 nM, 4 nM and 2 nM, respectively. XL999 can be used in the research of cancer.
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AZ8010
0 ImagesCat. No.: HY-164459CAS No.: 1035270-44-0Synonyms: AZ12908010AZ8010 (AZ12908010) is a potent FGFR1-3 inhibitor. AZ8010 has anti-proliferative activity and can be used for the research of cancer.
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TG 100801 Hydrochloride
0 ImagesCat. No.: HY-10187CAS No.: 1018069-81-2TG 100801 Hydrochloride is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
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PF 477736 (Standard)
0 ImagesCat. No.: HY-10032RCAS No.: 952021-60-2Synonyms: PF 00477736 (Standard)PF 477736 (Standard) is the analytical standard of PF 477736 (HY-10032). This product is intended for research and analytical applications. PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.
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FGFR1 inhibitor-15
0 ImagesCat. No.: HY-W261325CAS No.: 459137-97-4FGFR1 inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 of 27 μM. FGFR1 inhibitor-15 can be used in the study of cancer.
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Lucitanib (Standard)
0 ImagesCat. No.: HY-15391RCAS No.: 1058137-23-7Synonyms: E-3810 (Standard)Lucitanib (Standard) is the analytical standard of Lucitanib. This product is intended for research and analytical applications. Lucitanib (E-3810) is a novel dual inhibitor of VEGFR and FGFR, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50s of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively.
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FGFR1 inhibitor-16
0 ImagesCat. No.: HY-169710CAS No.: 606958-57-0FGFR1 inhibitor-16 (Compound 89) is an FGFR1 inhibitor. FGFR1 inhibitor-16 exhibits an inhibitory rate of 53.00% against FGFR1 at a concentration of 50 μM and 24.95% at 10 μM. FGFR1 inhibitor-16 can be used in the study of cancer.
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FGFR1 inhibitor-17
0 ImagesCat. No.: HY-169669CAS No.: 308298-51-3FGFR1 inhibitor-17 (Compound 92) is a potent FGFR1 inhibitor. FGFR1 inhibitor-17 is promising for research of cancers.
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E7090 (Standard)
0 ImagesCat. No.: HY-101466RCAS No.: 1622204-21-0E7090 (Standard) is the analytical standard of E7090 (HY-101466). This product is intended for research and analytical applications. E7090 is an orally available, potent, and selective FGFR inhibitor with IC50s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/FGFR2/FGFR3/FGFR4, respectively.
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TG 100572 hydrochloride (Standard)
0 ImagesCat. No.: HY-10185RCAS No.: 867331-64-4TG 100572 hydrochloride (Standard) is the analytical standard of TG 100572 hydrochloride (HY-10185). This product is intended for research and analytical applications. TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
