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Cat. No.: HY-W261325

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FGFR1 inhibitor-15

FGFR1 inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC₅₀ of 27 μM. FGFR1 inhibitor-15 can be used in the study of cancer.

For research use only. We do not sell to patients.

CAS No.: 459137-97-4
Formula: C₁₇H₁₃FN₄O
Molecular Weight:308.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

FGFR1 inhibitor-15 Chemical Structure

CAS No.: 459137-97-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

FGFR1 inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC₅₀ of 27 μM. FGFR1 inhibitor-15 can be used in the study of cancer^[1].

IC₅₀ & Target^[1]

FGFR1

27 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	IC₅₀	27 μM Compound: 23	Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins using KKKSPGEYVNIEFG peptide substrate by scintillation counting analysis Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins using KKKSPGEYVNIEFG peptide substrate by scintillation counting analysis	[PMID: 27017541]

Chemical Information

CAS No. 459137-97-4
Molecular Weight 308.31
Formula C₁₇H₁₃FN₄O
SMILES

O=C1C(C2=NC3=C(N2)C=CC=C3)=C(N(C1)C4=CC=C(C=C4)F)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gryshchenko AA, et al. Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1,2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1. Bioorg Med Chem. 2016 May 1;24(9):2053-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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