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Kinesin

Kinesin

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Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. The kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) in both the mitotic and the meiotic cell cycle. Kinesins also can be classified into three groups based on the position of their motor domains: N-terminal, C-terminal and internal kinesins. Conventional kinesin operates as a dimer, walking in a co-ordinated, hand-over-hand fashion along a microtubule protofilament.

Kinesins have important roles in chromosome separation, microtubule dynamics, spindle formation, cytokinesis and cell cycle progression. Roles of kinesins in diseases typically involve defective transport of cell components, transport of pathogens, or cell division.

Kinesin Isoform Specific Products:

Kinesin Isoform Comparison
Cat. No. Nom du produit Effet Pureté Chemical Structure
  • HY-124790
    KSP-IA
    		Inhibitor
    KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC50 value of 3.6 nM. KSP-IA inhibits cell mitosis.
    KSP-IA
  • HY-RS07292
    KIF6 Human Pre-designed siRNA Set A
    		Inhibitor

    KIF6 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    KIF6 Human Pre-designed siRNA Set A
  • HY-150265
    TNH
    		Activator
    TNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that can enter living cells and recruit proteins to cellular structures. TNH senses light signals and acts by recruiting proteins to kinetochores and releasing them from kinetochores (depending on CENP-E (kinesin-7)).
    TNH
  • HY-119407
    Terpendole E
    		Inhibitor
    Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase.
    Terpendole E
  • HY-177876
    Cenpemlin
    		Inhibitor
    Cenpemlin is a CENP-M inhibitor that disrupts the CENP-M/CENP-L interaction. Cenpemlin can be used for investigating centromere-kinetochore interactions and dynamic kinetochore assembly during cell division.
    Cenpemlin
  • HY-50759A
    Ispinesib mesylate
    		Inhibitor
    Ispinesib (SB-715992) mesylate is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
    Ispinesib mesylate
  • HY-177613
    ALN-12115
    		Inhibitor
    ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.
    ALN-12115
  • HY-170850
    MKLP2-IN-1
    		Inhibitor
    MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 with good oral bioavailability. MKLP2-IN-1 inhibits the microtubule-stimulated ATPase activity of recombinant MKLP2 in vitro and suppresses tumor growth in a mouse Calu-6 lung cancer model.
    MKLP2-IN-1
  • HY-RS07293
    Kif6 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Kif6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Kif6 Mouse Pre-designed siRNA Set A
  • HY-168725
    PROTAC KSP degrader 1
    		Degrader
    PROTAC KSP degrader 1 (Compound 21) is a PROTAC Degrader for kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC50 of 114.8 nM. PROTAC KSP degrader 1 inhibits the proliferation of HCT-116 with IC50 of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP degrader 1 exhibits antitumor efficacy in mouse model. (Blue: Ligand for E3 Ligase Cereblon (HY-103596); Blank: Linker (HY-168726); Pink: Target Protein Ligand (HY-168727))
    PROTAC KSP degrader 1
  • HY-164979
    KIF18A-IN-15
    		Inhibitor
    KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC50s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC50s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies.
    KIF18A-IN-15
  • HY-180170
    KIF18A-IN-18
    		Inhibitor
    KIF18A-IN-18 (Compound I) is a KIF18A inhibitor. KIF18A-IN-18 can be used in the research of chromosomally unstable tumors.
    KIF18A-IN-18
  • HY-180304
    CCT369834
    		Inhibitor
    CCT369834 is an ATP-competitive HSET inhibitor with an IC50 of 39 nM. CCT369834 is a trans-cyclooctene-tagged probe. CCT369834 and HSET specifically co-localize on mitotic spindles. CCT369834 can be used for the research of cancer.
    CCT369834
  • HY-168727
    KSP ligand 1
    KSP ligand 1 is a protein ligand that targets KSP (Kinesin), and it can be used to synthesize PROTAC KSP-IN-1 (HY-168725) for cancer research.
    KSP ligand 1
  • HY-162518
    Eg5-IN-3
    		Inhibitor
    Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A).
    Eg5-IN-3
  • HY-RS07261
    KIF14 Human Pre-designed siRNA Set A
    		Inhibitor

    KIF14 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    KIF14 Human Pre-designed siRNA Set A
  • HY-164980
    KIF18A-IN-16
    		Inhibitor
    KIF18A-IN-16 (Compound 15) is a fused ring KIF18A inhibitor. KIF18A-IN-16 can be used in oncology (e.g., colon, breast, lung cancer) studies.
    KIF18A-IN-16
  • HY-10084
    CK0106023
    		Inhibitor
    CK0106023 is a potent and specific allosteric inhibitor of KSP with a Ki value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice.
    CK0106023
  • HY-178511
    KIF18A-IN-17
    		Inhibitor
    KIF18A-IN-17 (Example 37A) is a KIF18A inhibitor with racemic form with an IC50 of 48 nM. KIF18A-IN-17 exhibits anti-proliferative activity against HT29 cells. KIF18A-IN-17 can be used for the study of cancers such as breast cancer and ovarian cancer.
    KIF18A-IN-17
  • HY-161898
    CENP-E-IN-3
    		Inhibitor
    CENP-E-IN-3 (compound 4) is a potent CENP-E inhibitor. CENP-E-IN-3 has the potential for the research of cancer.
    CENP-E-IN-3
Cat. No. Nom du produit / Synonyms Application Reactivity
Kinesin Isoform Comparison

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