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Cat. No.: HY-180304

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CCT369834

CCT369834 is an ATP-competitive HSET inhibitor with an IC₅₀ of 39 nM. CCT369834 is a trans-cyclooctene-tagged probe. CCT369834 and HSET specifically co-localize on mitotic spindles. CCT369834 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2902671-78-5
Formula: C₃₈H₄₉N₇O₇S
Molecular Weight:747.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CCT369834 Chemical Structure

CAS No.: 2902671-78-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

HSET

39 nM (IC₅₀)

All Kinesin Isoforms :

In Vitro

CCT369834 inhibits recombinant full-length HSET (IC₅₀ = 39 nM)^[1].
CCT369834 (3 μM; 45 min) shows clear Cy5-labeled mitotic spindle signals in proTAME-treated DLD1 4N cells, which overlap with endogenous HSET signals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2902671-78-5
Molecular Weight 747.90
Formula C₃₈H₄₉N₇O₇S
SMILES

O=C(N[C@H](CC(NC1=NC(C)=C(S1)C(OCCC)=O)=O)CCCN(CC#CCNC(O[C@H]2CCC/C=C/CC2)=O)C)C3=CC=CC(C4=NOC(C)=N4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Saint-Dizier F, et al. Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes. J Med Chem. 2023 Feb 23;66(4):2622-2645. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols
Purity & Documentation
References

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CCT369834

All Kinesin Isoforms