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Cat. No.: HY-10084

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CK0106023

CK0106023 is a potent and specific allosteric inhibitor of KSP with a K_i value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice.

For research use only. We do not sell to patients.

CAS No.: 336115-72-1
Formula: C₃₀H₃₂BrClN₄O₂
Molecular Weight:595.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

CK0106023 Chemical Structure

CAS No.: 336115-72-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Kinesin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	3 μM Compound: CK0106023	Cytotoxicity against human A2780 cells after 72 hrs by MTT assay Cytotoxicity against human A2780 cells after 72 hrs by MTT assay	[PMID: 20934346]
A549	IC₅₀	4.89 μM Compound: CK0106023	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 21856161]
A549	IC₅₀	7.02 μM Compound: CK0106023	Antiproliferative activity against human A549 cells after 24 hrs by SRB assay Antiproliferative activity against human A549 cells after 24 hrs by SRB assay	[PMID: 20537544]
AGS	IC₅₀	5.1 μM Compound: CK0106023	Antiproliferative activity against human AGS cells after 24 hrs by SRB assay Antiproliferative activity against human AGS cells after 24 hrs by SRB assay	[PMID: 20537544]
AGS	IC₅₀	6.7 μM Compound: CK0106023	Cytotoxicity against human AGS cells after 48 hrs by SRB assay Cytotoxicity against human AGS cells after 48 hrs by SRB assay	[PMID: 21856161]
HCT-116	IC₅₀	0.94 μM Compound: CK0106023	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 20934346]
HepG2	IC₅₀	>10 μM Compound: CK0106023	Antiproliferative activity against human HepG2 cells after 24 hrs by SRB assay Antiproliferative activity against human HepG2 cells after 24 hrs by SRB assay	[PMID: 20537544]
HepG2	IC₅₀	2.1 μM Compound: CK0106023	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 20934346]
HT-29	IC₅₀	3.33 μM Compound: CK0106023	Antiproliferative activity against human HT-29 cells after 24 hrs by SRB assay Antiproliferative activity against human HT-29 cells after 24 hrs by SRB assay	[PMID: 20537544]
PC-3	IC₅₀	>10 μM Compound: CK0106023	Antiproliferative activity against human PC3 cells after 24 hrs by SRB assay Antiproliferative activity against human PC3 cells after 24 hrs by SRB assay	[PMID: 20537544]

Chemical Information

CAS No. 336115-72-1
Molecular Weight 595.96
Formula C₃₀H₃₂BrClN₄O₂
SMILES

O=C1N(CC2=CC=CC=C2)C(C(CC)N(CCCN(C)C)C(C(C=C3)=CC=C3Br)=O)=NC4=C1C=CC(Cl)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. You-Ling Fan. End-capped polyarylene polyethers, articles made therefrom and process for preparing such polyarylene polyethers. EP0106023B1. 1988 March 30.

[2]. Sakowicz R, et al. Antitumor activity of a kinesin inhibitor. Cancer Res. 2004 May 1;64(9):3276-80. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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CK0106023

All Kinesin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CK0106023 Related Classifications

HY-10084 Related Classifications