2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP
  5. MMP-10 Isoform

MMP-10

MMP-10 (matrix metalloproteinase-10), also known as stromelysin-2, is a member of the matrix metalloproteinase family that participates in extracellular matrix (ECM) turnover by degrading matrix-associated substrates and contributing to tissue remodeling processes[1][2]. Within the broader MMP signaling network, MMP-10 is linked to ECM remodeling during repair, angiogenesis, and pathological tissue reorganization, thereby influencing cellular responses associated with injury and disease progression[2][3]. Mechanistically, increased MMP-10 expression has been reported in acute kidney injury (AKI), chronic kidney disease (CKD), and renal cell carcinoma, supporting a role in tissue injury responses and disease-associated remodeling programs[3]. Disease studies further demonstrate that MMP-10 contributes to pathological phenotypes, including maintenance of lung cancer stem cell functions and promotion of tumor initiation and metastatic potential[4]. In experimental pulmonary arterial hypertension models, active MMP-10 enhances pulmonary artery smooth muscle cell proliferation and migration through increased cyclin D1 and proliferating cell nuclear antigen expression, linking MMP-10 to vascular remodeling mechanisms. Compared with the closely related stromelysin family member MMP-3, MMP-10 may display higher tissue abundance but lower enzymatic activity in certain tumor settings, indicating distinct functional contributions despite structural similarity[5]. For experimental applications, MMP-10 is widely investigated as a mechanistic biomarker and therapeutic target in kidney disease, cancer, and vascular remodeling models, where modulation of MMP-10 activity provides a useful framework for studying ECM-dependent disease processes[3].

Cat. No. Product Name Effect Purity
  • HY-124029
    BI-4394
    		Inhibitor 99.09%
    BI-4394 (MMP13-IN-3), a chemical probe, is a potent, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis. BI-4394 is >1000 selective over other MMPs.
  • HY-P2185A
    NFF-3 TFA
    		Chemical
    NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity.
  • HY-161285
    MMP-9/10-IN-2
    		Inhibitor 99.87%
    MMP-9/10-IN-2 (compound 6e) is a potent inhibitor of MMP10 and MMP9, with IC50 of 0.076 μM for MMP10, and 93.18% inhibition at 0.5 μM for MMP9. MMP-9/10-IN-2 plays an important role in anti-tumor.
  • HY-P3012
    Cathepsin G
    		Activator
    Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating ERK1/2 and p38 MAPK signaling, and mediating PKCζ membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases.
  • HY-181654
    Snail IN-1
    		Inhibitor 98.27%
    Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail-CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis.
  • HY-171804
    Linvemastat
    		Inhibitor 98.30%
    Linvemastat (Compound FC-4) is an orally active MMP-12 inhibitor (IC50: < 10  nM) with high selectivity of MMP-1, -2, -3, -7, -9, -10 and -14. Linvemastat significantly attenuates lung fibrosis in Bleomycin (HY-108345) induced unilateral lung fibrosis mice model and potently reduces kidney damage, interstitial inflammation or fibrosis in kidney fibrosis model of unilateral ureteral occlusion. Linvemastat can be used for inflammatory diseases research, such as idiopathie pulmonary fibrosis (IPF), inflammatory bowel disease (IBD) and asthma.
  • HY-P2185
    NFF-3
    		Chemical
    NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity.
  • HY-117464
    CM-352
    		Inhibitor
    CM-352 (compound 5) is an inhibitor of matrix metalloproteinases (MMPs) (MMP-3: IC50=15 nM; MMP-10: IC50=12 nM). CM-352 has significant antifibrinolytic activity (EC50=0.7 nM) and can significantly prolong blood coagulation time. CM-352 can be used in anti-bleeding research.
Cat. No. Product Name / Synonyms Species Source