Endogenous Metabolite

Related Products

Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health^[1]^[2]^[3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets^[1]^[2]^[3].

References:

[1]. Seyedsayamdost MR. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):301-311.

[2]. Ruiz B, et al. Production of microbial secondary metabolites: regulation by the carbon source. Crit Rev Microbiol. 2010 May;36(2):146-67.

[3]. Wishart DS. Metabolomics for Investigating Physiological and Pathophysiological Processes. Physiol Rev. 2019 Oct 1;99(4):1819-1875.

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8492)
Antibodies (477)
Endogenous Metabolite Isoform Comparison

By Effects:	Inhibitors (66) Agonists (3) Controls (2) Antagonist (1) Activators (7) Modulators (9) Chemicals (14) Inducers (6)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W742088

Nicotinic acid riboside-d₄		98.65%
Nicotinic acid riboside-d₄ is the deuterium labeled Nicotinic acid riboside (HY-W104368). Nicotinic acid riboside is a NAD+ precursor in human cells. Nicotinic acid riboside is an authentic intermediate of human NAD+ metabolism.

HY-W080443

O-allylvanillin		98.41%
O-allylvanillin is O-allylchalcone derivative with anti-cancer effects. O-allylvanillin inhibits THP-1, HL60, Hep-G2, MCF-7 cells growth with IC₅₀ values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectively.

HY-E70283

Recombinant endoglycoceramidase II assisted by activator II
Recombinant endoglycoceramidase II assisted by activator II is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible.

HY-W015061S

N-(Phenylacetyl-d₅)glycine		≥99.0%
N-(Phenylacetyl-d₅)glycine is the deuterium labeled Phenylacetylglycine. Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion.

HY-Y0289S1

1-Dodecanol-d₂₅		98.09%
1-Dodecanol-d₂₅ is the deuterium labeled 1-Dodecanol. 1-Dodecanol is an endogenous metabolite.

HY-W708332

3-Methylvaleric acid-d₁₁		98.92%
3-Methylvaleric acid-d₁₁ is the deuterium labeled 3-Methylvaleric Acid (HY-W010513). 3-Methylvaleric Acid is a branched alkanoic acid. 3-Methylvaleric Acid can be utilized by Pseudomonas citronettotis as a sole carbon source for its growth. 3-Methylvaleric Acid derivatives exhibit anti-hyperalgesic and anticonvulsant activities.

HY-W013159S

2'-Deoxyguanosine 5'-monophosphate-¹³C₁₀,¹⁵N₅ disodium		98.97%
2'-Deoxyguanosine 5'-monophosphate-¹³C₁₀,¹⁵N₅ (dGMP-¹³C₁₀,¹⁵N₅) disodium is the ¹³C and ¹⁵N labeled 2'-Deoxyguanosine 5'-monophosphate disodium (HY-W013159). 2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis.

HY-104026CS

L-Kynurenine-¹³C₁₀ sulfate hemihydrate		99.90%
L-Kynurenine-¹³C10 (sulfate hemihydrate) is the ¹³C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype.

HY-W019700

PNU-100440		99.67%
PNU-100440 is the metabolite of Linezolid (HY-10394).

HY-P2921D

Uricase, candida utilis
Uricase, candida utilis (Uox, candida utilis) is a uricase (urate oxidase) derived from Candida utilis. Uricase, candida utilis converts uric acid into allantoin. The absence of Uricase in mammals causes kidney diseases resulting from uric acid accumulation. Uricase, candida utilis can be used for research on chronic refractory gout and hyperuricemia.

HY-107372H

UTP trisodium salt, 100 mM Solution, PCR Grade
UTP (Uridine 5'-triphosphate) trisodium salt, 100 mM Solution, PCR Grade is a solution prepared from uridine triphosphate at a concentration of 100 mM, free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. Uridine triphosphate (HY-107372) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors.

HY-W131302

Ethylenediaminediacetic acid		98.0%
Ethylenediaminediacetic acid (N,N-Ethylenediglycine) is an important ligand that enhances the antiproliferative activity of metal complexes. The complexes formed by ethylenediacetic acid and metal ions exhibited significant antiproliferative properties in MCF-7 cancer cell line. The metal complexes of ethylenediacetic acid were able to interact with DNA and were studied by CD and EPR spectroscopy techniques. Ethylenediaminediacetic acid and its metal complexes were able to induce cell cycle arrest at the G(0)/G(1) phase. The crystal structure analysis of ethylenediacetic acid provided important structural information for understanding its biological activity.

HY-109506S9

DPPC-¹³C₂
DPPC-13C2 is a deuterated labeled DPPC. DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice.

HY-124904

LY-195448		99.04%
LY-195448 is a phenethanolamine that exhibits anti-tumour activity across various murine tumour models.

HY-B0355R

Ginkgolide A (Standard)
Ginkgolide A (Standard) is the analytical standard of Ginkgolide A. This product is intended for research and analytical applications. Ginkgolide A (BN-52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist.

HY-116003

12,13-DiHOME		99.5%
12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders.

HY-109506S7

DPPC-d₇₁		99.0%
DPPC-d₇₁ is deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in

HY-164091

Mevalonate 5-phosphate
Mevalonate 5-phosphate is a substrate of phosphomevalonate kinase and mevalonate-5-phosphate decarboxylase.

HY-131668

9-POHSA		98.5%
9-POHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-POHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression.

HY-W008385S

H-HoArg-OH-d₄
H-HoArg-OH-d₄ is a deuterium labeled H-HoArg-OH (HY-W008385). H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Related Products (8492)

Antibodies (477)

Endogenous Metabolite Isoform Comparison

Endogenous Metabolite Related Products (8492):