12,13-DiHOME
Based on 1 Customer Validation
12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.5%
- CAS No.: 263399-35-5
- 화학식: C18H34O4
- 분자량:314.46
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보관:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice fed a high-fat diet[1]
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Dosage:1 μg/kg
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Administration:Retro-orbitally injection; once daily for 2 weeks
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Result:Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA.
Increased BAT-specific lipid uptake and improved oral lipid tolerance.
Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake.
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Animal Model:To explore the biosynthesis of (±)12, 13-dihome in mice in vivo[1]
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Dosage:
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Administration:7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h
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Result:Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation.
Chemical Information
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CAS No. 263399-35-5
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Appearance Liquid
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분자량 314.46
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화학식 C18H34O4
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Color Colorless to light yellow
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SMILES
CCCCCC(C(C/C=C\CCCCCCCC(O)=O)O)O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Solution, -20°C, 2 years
Protocol
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Large-size fat particle sorting
Large-size fat particle sorting is widely used to isolate cells up to 200 μm in diameter. Single-cell flow sorting will allow greater insight into adipocyte heterogeneity by identifying gene expression, protein composition, and metabolic signatures at the single-cell level.
순도&문서
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Data Sheet (265 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
12,13-DiHOME Related Classifications
HY-116003 Related Classifications
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