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Cat. No.: HY-116003

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12,13-DiHOME

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12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders.

For research use only. We do not sell to patients.

Purity: 99.5%
CAS No.: 263399-35-5
Formula: C₁₈H₃₄O₄
Molecular Weight:314.46

Storage:

Solution, -20°C, 2 years

12,13-DiHOME Chemical Structure

CAS No.: 263399-35-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vivo

12,13-DiHOME (1 μg/kg; retro-orbitally injection; once daily for 2 weeks) acutely decreases levels of serum triglycerides in mice with high-fat diet model, and increases BAT uptake to defend cold^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice fed a high-fat diet^[1]
Dosage:

1 μg/kg
Administration:

Retro-orbitally injection; once daily for 2 weeks
Result:

Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA.
Increased BAT-specific lipid uptake and improved oral lipid tolerance.
Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake.

Animal Model:

To explore the biosynthesis of (±)12, 13-dihome in mice in vivo^[1]
Dosage:
Administration:

7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h
Result:

Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation.

Chemical Information

CAS No. 263399-35-5
Appearance Liquid
Molecular Weight 314.46
Formula C₁₈H₃₄O₄
Color Colorless to light yellow
SMILES

CCCCCC(C(C/C=C\CCCCCCCC(O)=O)O)O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lynes MD, et al. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May;23(5):631-637. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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12,13-DiHOME

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

12,13-DiHOME Related Classifications

HY-116003 Related Classifications