N-(Phenylacetyl-d5)glycine
N-(Phenylacetyl-d5)glycine is the deuterium labeled Phenylacetylglycine. Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion.
For research use only. We do not sell to patients.
- CAS No.: 1189920-31-7
- Formula: C10H6D5NO3
- Molecular Weight:198.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189920-31-7
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Unlabeled Cas 500-98-1
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Appearance Solid
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Molecular Weight 198.23
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Formula C10H6D5NO3
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Color White to off-white
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SMILES
OC(CNC(CC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=O)=O
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Synonyms
2-(2-Phenylacetamido)acetic acid-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMF : ≥ 25 mg/mL (126.12 mM)
DMSO : ≥ 10 mg/mL (50.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : ≥ 1 mg/mL (5.04 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Xu X, et al. The gut microbial metabolite phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion through activating β2AR. Arch Biochem Biophys. 2021 Jan 15;697:108720. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO / DMF | 1 mM | 5.0446 mL | 25.2232 mL | 50.4465 mL | 126.1161 mL |
| 5 mM | 1.0089 mL | 5.0446 mL | 10.0893 mL | 25.2232 mL | |
| DMSO / DMF | 10 mM | 0.5045 mL | 2.5223 mL | 5.0446 mL | 12.6116 mL |
| 15 mM | 0.3363 mL | 1.6815 mL | 3.3631 mL | 8.4077 mL | |
| 20 mM | 0.2522 mL | 1.2612 mL | 2.5223 mL | 6.3058 mL | |
| 25 mM | 0.2018 mL | 1.0089 mL | 2.0179 mL | 5.0446 mL | |
| 30 mM | 0.1682 mL | 0.8408 mL | 1.6815 mL | 4.2039 mL | |
| 40 mM | 0.1261 mL | 0.6306 mL | 1.2612 mL | 3.1529 mL | |
| 50 mM | 0.1009 mL | 0.5045 mL | 1.0089 mL | 2.5223 mL | |
| DMF | 60 mM | 0.0841 mL | 0.4204 mL | 0.8408 mL | 2.1019 mL |
| 80 mM | 0.0631 mL | 0.3153 mL | 0.6306 mL | 1.5765 mL | |
| 100 mM | 0.0504 mL | 0.2522 mL | 0.5045 mL | 1.2612 mL |
N-(Phenylacetyl-d5)glycine Related Classifications
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