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  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Art. -Nr. Produktname Wirkung Reinheit Chemical Structure
  • HY-149550
    1,2-Eucin(13Z)-olein
    1,2-Eucin(13Z)-olein (compound 48) is a triacylglycerol that contains palmitic acid,? oleic acid, and arachidonic acid .
    1,2-Eucin(13Z)-olein
  • HY-115464
    NC1153
    NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity.
    NC1153
  • HY-E70630
    Deoxycytidine Kinase, Human
    Deoxycytidine Kinase, Human (EC 2.7.1.74) is a rate-limiting enzyme in the de novo pathway. Deoxycytidine Kinase, Human captures extracellular deoxyribonucleosides for use in intracellular deoxyribonucleotide metabolism. Deoxycytidine Kinase, Human functions as a dimer in cells to phosphorylate deoxycytidine as its major substrate as well as deoxyadenosine and deoxyguanosine and can activate various nucleoside analogue therapeutics.
    Deoxycytidine Kinase, Human
  • HY-30219R
    D-(+)-Phenyllactic acid (Standard)
    D-​(+)​-​Phenyllactic acid (Standard) is the analytical standard of D-​(+)​-​Phenyllactic acid. This product is intended for research and analytical applications. D-​(+)​-​Phenyllactic acid is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits a range of Gram-positive from humans and foodstuffs and Gram-negative bacteria found in humans[1].
    D-(+)-Phenyllactic acid (Standard)
  • HY-N10256
    Varioxepine A
    Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum.
    Varioxepine A
  • HY-N0537S4
    Xylose-5-13C
    Xylose-5-13C is the 13C labeled Xylose.
    Xylose-5-<sup>13</sup>C
  • HY-113200
    N1-Acetylspermine
    N1-Acetylspermine is an endogenous metabolite present in Urine that can be used for the research of Leukemia.
    N1-Acetylspermine
  • HY-W101415R
    1-Phenyl-2-propanol (Standard)
    1-Phenyl-2-propanol (Standard) is the analytical standard of 1-Phenyl-2-propanol. This product is intended for research and analytical applications. 1-Phenyl-2-propanol (Benzylmethylcarbinol) is a chiral secondary alcohol and a metabolite of n-propylbenzene.
    1-Phenyl-2-propanol (Standard)
  • HY-125818S5
    Cytidine-5'-triphosphate-15N3,d14 dilithium
    Cytidine-5'-triphosphate-15N3,d14 (Cytidine triphosphate-15N3,d14 dilithium; 5'-CTP-15N3,d14) dilithium is deuterium and 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5'-triphosphate-<sup>15</sup>N<sub>3</sub>,d<sub>14</sub> dilithium
  • HY-B1178S2
    (Rac)-Cotinine-d7
    (Rac)-Cotinine-d7 is deuterium labeled Cotinine.
    (Rac)-Cotinine-d<sub>7</sub>
  • HY-E70920
    NiFe-type cytoplasmic hydrogenase, Pyrococcus furiosus
    NiFe-type cytoplasmic hydrogenase, Pyrococcus furiosus contains a minimum of two subunits known as the small (S) and large (L) subunits. The small subunit contains three iron-sulfur clusters while the large subunit contains the active site, a nickel-iron center which is connected to the solvent by a molecular tunnel.
    NiFe-type cytoplasmic hydrogenase, Pyrococcus furiosus
  • HY-168167
    BuChE-IN-14
    BuChE-IN-14 is a novel compound that selectively inhibits acetylcholinesterase (AChE) activity. BuChE-IN-14 showed a concentration-dependent inhibitory effect on AChE in rat brain in vitro experiments. BuChE-IN-14 can increase the extracellular acetylcholine (ACh) concentration in the rat hippocampus and striatum at a certain dose. BuChE-IN-14 may help improve memory impairment caused by cholinergic dysfunction.
    BuChE-IN-14
  • HY-P2879C
    Cholesterol esterase, schizophyllum commune
    Cholesterol esterase, Schizophyllum commune is an enzyme that catalyzes the hydrolysis of cholesterol esters into free cholesterol and fatty acids, facilitating the absorption of cholesterol in the intestine. Cholesterol esterase, Schizophyllum commune can be used in combination with cholesterol oxidase to measure cholesterol content.
    Cholesterol esterase, schizophyllum commune
  • HY-B1674R
    (±)-Leucine (Standard)
    (±)-Leucine (Standard) is the analytical standard of (±)-Leucine. This product is intended for research and analytical applications. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%.
    (±)-Leucine (Standard)
  • HY-125684
    Trichodecenin I
    Trichodecenin I, a fungal metabolite, is a peptaibol composed of 7 amino acid residues.
    Trichodecenin I
  • HY-W768934
    L-Gulono-1,4-lactone-13C6
    L-Gulono-1,4-lactone-13C6 (L-Gulonolactone-13C6) is the 13C-labeled L-Gulono-1,4-lactone (HY-W016628). L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
    L-Gulono-1,4-lactone-<sup>13</sup>C<sub>6</sub>
  • HY-W005241R
    5-Hydroxymethyl-2-furancarboxylic acid (Standard)
    5-Hydroxymethyl-2-furancarboxylic acid (Standard) is the analytical standard of 5-Hydroxymethyl-2-furancarboxylic acid. This product is intended for research and analytical applications. 5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural (HMF) in the body and eliminated renally.
    5-Hydroxymethyl-2-furancarboxylic acid (Standard)
  • HY-W011340R
    5-Hydroxy flunixin (Standard)
    5-Hydroxy flunixin (Standard) is the analytical standard of 5-Hydroxy flunixin. This product is intended for research and analytical applications. 5-Hydroxy flunixin, the principal metabolite of Flunixin (HY-121046), retains the Flunixin's anti-inflammatory properties and plays a significant role in mitigating pain and inflammation in various veterinary applications. It assists in alleviating conditions such as colic in horses, musculoskeletal disorders, and infectious diseases in cattle, while also supporting the management of mastitis-metritis-agalactia syndrome in sows.
    5-Hydroxy flunixin (Standard)
  • HY-W015060S1
    2-(2-Methylbenzamido)acetic acid-d2
    2-(2-Methylbenzamido)acetic acid-d2 is the deuterium labeled 2-(2-Methylbenzamido)acetic acid. 2-(2-Methylbenzamido)acetic acid is a metabolite detected in urine.
    2-(2-Methylbenzamido)acetic acid-d<sub>2</sub>
  • HY-107494AR
    all-trans-4-Oxoretinoic acid (Standard)
    all-trans-4-Oxoretinoic acid (Standard) is the analytical standard of all-trans-4-Oxoretinoic acid. This product is intended for research and analytical applications. all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
    all-trans-4-Oxoretinoic acid (Standard)
Art. -Nr. Produktname / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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