2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124660A
    A-395N
    A-395N serves as a control probe for A-395, a highly potent and selective chemical probe targeting the polycomb protein EED, a key player in Polycomb repressive complex 2 (PRC2) responsible for transcriptional repression via histone H3K27 methylation. While A-395N bears structural similarities to A-395, it demonstrates no pharmacological activity in biochemical or cellular assays, making it an ideal control compound.
    A-395N
  • HY-Y1314R
    Dimethyl sulfone (Standard)
    Dimethyl sulfone (Standard) is the analytical standard of Dimethyl sulfone. This product is intended for research and analytical applications. Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective.
    Dimethyl sulfone (Standard)
  • HY-W002587R
    4-Hydroxy-3-methylbenzoic acid (Standard)
    4-Hydroxy-3-methylbenzoic acid is a normal organic acid identified in urine specimens from a healthy population.
    4-Hydroxy-3-methylbenzoic acid (Standard)
  • HY-113238S1
    Lithocholic acid 3-sulfate-d4（sodium salt）
    Lithocholic acid 3-sulfate-d4（sodium salt） is the deuterium labeled Lithocholic acid 3-sulfate.
    Lithocholic acid 3-sulfate-d<sub>4</sub>（sodium salt）
  • HY-138270
    Tetrahydropteroylpentaglutamate
    		Inhibitor
    Tetrahydropteroylpentaglutamate (H4PteGlu5) is an inhibitor for 10-CHO-THF dehydrogenase with a Kd of 20 nM through binding of an irreversible o 10-CHO-THF dehydrogenase-H4PteGlu5 complex.
    Tetrahydropteroylpentaglutamate
  • HY-W107616R
    3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard)
    3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard) is the analytical standard of 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (HY-W107616). This product is intended for research and analytical applications. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43.
    3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard)
  • HY-W747575
    (+/-)13-HODE cholesteryl ester
    (±)13-HODE cholesteryl ester is originally extracted from atherosclerotic lesions1 and shown to be produced by Cu2+-catalyzed oxidation of LDL. Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 13-HODE cholesteryl ester.
    (+/-)13-HODE cholesteryl ester
  • HY-180328
    3''-Deamino-3''-hydroxykanamycin B
    3''-Deamino-3''-hydroxykanamycin B (NK-1012-1) is a kanamycin antibiotic. 3''-Deamino-3''-hydroxykanamycin B can be produced by S. tenebrarius. 3''-Deamino-3''-hydroxykanamycin B is effective against E. coli ATCC 25922 and E. coli CCARM 1A020, with MIC values of 128 μg/mL.
    3''-Deamino-3''-hydroxykanamycin B
  • HY-113102B
    9(Z),11(Z)-Octadecadienoic acid
    9(Z),11(Z)-octadecadienoic acid is an isomer of linoleic acid and has antitumor activity (EC 50 = 446.1 µM).
    9(Z),11(Z)-Octadecadienoic acid
  • HY-N0455AS9
    L-Arginine-15N4,d7 hydrochloride
    L-Arginine-15N4,d7 (hydrochloride) is the deuterium and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
    L-Arginine-<sup>15</sup>N<sub>4</sub>,d<sub>7</sub> hydrochloride
  • HY-134062
    7-Methyl-6-mercaptopurine
    7-Methyl-6-mercaptopurine (Compound 4) is a purine derivative and a substrate for thiopurine methyltransferase (TPMT) with Km and Vmax values of 231 μM and 2340 U/mg protein, respectively.
    7-Methyl-6-mercaptopurine
  • HY-N13018
    M145724
    M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite, which can be isolated from Streptomyces albus.
    M145724
  • HY-113049
    Phosphoenolpyruvic acid
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid also exhibits cytoprotective and anti-oxidative properties.
    Phosphoenolpyruvic acid
  • HY-114296S
    2,3-Oxidosqualene-d6
    2,3-Oxidosqualene-d6 (Squalene oxide-d6) is a deuterium labeled 2,3-Oxidosqualene (HY-114296). 2,3-Oxidosqualene (Squalene oxide) is a sterol biosynthesis precursor intermediate.2,3-Oxidosqualene participates in cyclization pathways that form sterols and triterpenes, and contributes to introduction of their characteristic 3-hydroxyl group.2,3-Oxidosqualene forms metabolically from squalene in rat liver homogenates under sterol synthesis conditions.2,3-Oxidosqualene converts to sterols including cholesterol, lathosterol, and lanost-8-en-3β-ol in rat liver homogenates under anaerobic conditions.
    2,3-Oxidosqualene-d<sub>6</sub>
  • HY-130466R
    Stearoyl-L-carnitine chloride (Standard)
    Stearoyl-L-carnitine (chloride) (Standard) is the analytical standard of Stearoyl-L-carnitine (chloride). This product is intended for research and analytical applications. Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM.
    Stearoyl-L-carnitine chloride (Standard)
  • HY-W702290
    2-Methyldecanenitrile
    2-Methyldecanenitrile is a compound with biological activity for fragrance applications. 2-Methyldecanenitrile exhibits a rich peach aroma with frankincense undertones in perfume compositions. 2-Methyldecanenitrile is stable across the entire pH range, enabling it to create a stable fruity effect at low concentrations in any application.
    2-Methyldecanenitrile
  • HY-114695
    Prostaglandin F2α-1-glyceryl ester
    Prostaglandin F2α-1-glyceryl ester can be oxidized by 15-hydroxyprostaglandin dehydrogenase (15-HPGDH).
    Prostaglandin F2α-1-glyceryl ester
  • HY-113083R
    Acetaminophen glucuronide (Standard)
    Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
    Acetaminophen glucuronide (Standard)
  • HY-W068771R
    (E)-3-(4-Methoxyphenyl)acrylic acid (Standard)
    (E)-3-(4-Methoxyphenyl)acrylic acid (compound 3) is isolated from Arachis hypogaea, Scrophularia buergeriana Miquel, Aquilegia vulgaris, Anigozanthos preissii and so on. (E)-3-(4-Methoxyphenyl)acrylic acid shows significant hepatoprotective activity, anti-amnesic, cognition-enhancing activity, antihyperglycemic, and neuroprotective activities.
    (E)-3-(4-Methoxyphenyl)acrylic acid (Standard)
  • HY-W654136
    2'-Deoxycytidine-2'-13C
    2'-Deoxycytidine-2'-13C is 13C labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, can inhibit biological effects of Bromodeoxyuridine (Brdu). 2'-Deoxycytidine is essential for the synthesis of nucleic acids, that can be used for the research of cancer.
    2'-Deoxycytidine-2'-<sup>13</sup>C
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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