2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. VD/VDR

VD/VDR

Vitamin D; Vitamin D receptor

VD/VDR

Related Products

PDF 0.3 MB

Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15439
    (24S)-24,25-Dihydroxyvitamin D3
    (24S)-24,25-Dihydroxyvitamin D3 ((24S)-24,25-Dihydroxycholecalciferol) is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs.
    (24S)-24,25-Dihydroxyvitamin D3
  • HY-15329
    Maxacalcitol-d6
    		Activator
    Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.
    Maxacalcitol-d<sub>6</sub>
  • HY-B1014
    Acenocoumarol
    		Antagonist 99.17%
    Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist. Acenocoumarol inhibits MAPK/ERK/JNK signaling pathway, reduces the nuclear translocation of NF-κB p65, activates Akt/GSK3β signaling pathway. Acenocoumarol induces apoptosis in cell A549, arrests cell cycle at S phase.
    Acenocoumarol
  • HY-A0245
    Dihydrotachysterol
    		Modulator 99.86%
    Dihydrotachysterol is a synthetic analog of vitamin D. Dihydrotachysterol can be used to for the research of hypocalcemia (lack of calcium in the blood) and hypoparathyroidism (lack of parathyroid hormone in the body) .
    Dihydrotachysterol
  • HY-15266
    24R-Calcipotriol
    		Activator
    24R-Calcipotriol (PRI 2202; Impurity D of Calcipotriol), an isomer of Calcipotriol (HY-10001), is a synthetic vitamin D analog. 24R-Calcipotriol exhibits synergistic antiproliferative effects with low-dose cytostatics in in vitro. 24R-Calcipotriol produces tumor growth inhibition when combined with Cyclophosphamide (HY-17420) and Cisplatin (HY-17394) in mice models. 24R-Calcipotriol can increase serum calcium levels and reduce blood leukocyte counts. 24R-Calcipotriol can be used for the research of mammary cancer and Lewis lung cancer.
    24R-Calcipotriol
  • HY-32342
    Falecalcitriol
    		Activator 99.90%
    Falecalcitriol(Fulstan; Hornel) is an analog of calcitriol; has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo.
    Falecalcitriol
  • HY-32351S
    Calcifediol-d3
    		98.96%
    Calcifediol-d3 is a deuterium labeled Calcifediol. Calcifediol, is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol-d<sub>3</sub>
  • HY-32340
    Lexacalcitol
    		Activator
    Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases.
    Lexacalcitol
  • HY-N6614
    L-Galactose
    		98.0%
    L-Galactose is a key intermediate in the de novo synthesis of vitamin C (L-ascorbic acid) in plants. It is converted into L-ascorbic acid by participating in the VTC2 cycle and enzymatic steps, exerting antioxidant activities, maintaining cell structure, and participating in the carbon flow distribution of photosynthesis. L-Galactose can be used to study the analysis of the synthesis pathway of vitamin C in plant physiology.
    L-Galactose
  • HY-A0020S
    Eldecalcitol-d6
    		Activator 99.53%
    Eldecalcitol-d6 is the deuterium labeled Eldecalcitol. Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis.
    Eldecalcitol-d<sub>6</sub>
  • HY-15330
    Vitamin D2-d3
    		Activator 98.57%
    Vitamin D2-d3 (Ergocalciferol-d3) is the deuterium labeled vitamin D2 (HY-76542), where the C-6 and C-19 protons are replaced by deuterium. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D.
    Vitamin D2-d<sub>3</sub>
  • HY-76915
    24, 25-Dihydroxy VD3
    		Activator 98.55%
    24, 25-Dihydroxy VD3 is a compound closely related to 1,25-dihydroxyvitamin D3 and is the active form of vitamin D3.
    24, 25-Dihydroxy VD3
  • HY-76585
    Paricalcitol-d6
    		Activator 99.85%
    Paricalcitol-d6 is the deuterium labeled Paricalcitol. Paricalcitol is a agent used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
    Paricalcitol-d<sub>6</sub>
  • HY-15830
    25,26-Dihydroxyvitamin D3
    25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia.
    25,26-Dihydroxyvitamin D3
  • HY-A0145
    Phenprocoumon
    		Antagonist 98.02%
    Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
    Phenprocoumon
  • HY-131492
    Δ4-Dafachronic acid
    		Ligand
    Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology.
    Δ4-Dafachronic acid
  • HY-15328
    25-Hydroxy VD2-d6
    		Activator 98.18%
    25-Hydroxy VD2-d6 is the deuterium labeled 25-Hydroxy VD2.
    25-Hydroxy VD2-d<sub>6</sub>
  • HY-13249
    1alpha-Hydroxy VD4
    		Activator 98.41%
    1alpha-Hydroxy VD4, a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells.
    1alpha-Hydroxy VD4
  • HY-B0325
    Phenindione
    		Antagonist 98.21%
    Phenindione is an anticoagulant and can act as a vitamin K antagonist.
    Phenindione
  • HY-15265
    Impurity F of Calcipotriol
    		Activator 99.40%
    Impurity F of Calcipotriol is a Vitamin D analog and an impurity of Calcipotriene (HY-10001).
    Impurity F of Calcipotriol
Cat. No. Product Name / Synonyms Application Reactivity