Impurity F of Calcipotriol
Based on 1 Customer Validation
Impurity F of Calcipotriol is a Vitamin D analog and an impurity of Calcipotriene (HY-10001).
For research use only. We do not sell to patients.
- Purity : 97.64%
- CAS No.: 112875-61-3
- Formula: C39H68O3Si2
- Molecular Weight:641.13
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Storage:
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-10001
Calcipotriol -
HY-15266
24R-Calcipotriol -
HY-75035
Calcipotriol Impurity C -
HY-50919
Paricalcitol -
HY-10001A
Calcipotriol monohydrate -
HY-32341
Seocalcitol -
HY-32342
Falecalcitriol -
HY-10001R
Calcipotriol (Standard) -
HY-76814
Calcitriol-d6 -
HY-32339
Maxacalcitol -
HY-15264
MC 1046 -
HY-10003
Alfacalcidol
Biological Activity
Description
In Vitro
Calcipotriol Impurity F (Compound XI) can serve as a synthetic intermediate or by-product for investigating the synthetic process or degradation pathway of Calcipotriol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 112875-61-3
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Appearance Solid
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Molecular Weight 641.13
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Formula C39H68O3Si2
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Color White to off-white
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SMILES
C[C@]1(CCC/2)[C@@](C2=C\C=C3C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C\3=C)([H])CC[C@]1([H])[C@H](C)/C=C/[C@H](C4CC4)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (38.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (1.95 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * The compound is unstable in solutions, freshly prepared is recommended.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.5597 mL | 7.7987 mL | 15.5975 mL | 38.9937 mL |
| 5 mM | 0.3119 mL | 1.5597 mL | 3.1195 mL | 7.7987 mL | |
| 10 mM | 0.1560 mL | 0.7799 mL | 1.5597 mL | 3.8994 mL | |
| 15 mM | 0.1040 mL | 0.5199 mL | 1.0398 mL | 2.5996 mL | |
| 20 mM | 0.0780 mL | 0.3899 mL | 0.7799 mL | 1.9497 mL | |
| 25 mM | 0.0624 mL | 0.3119 mL | 0.6239 mL | 1.5597 mL | |
| 30 mM | 0.0520 mL | 0.2600 mL | 0.5199 mL | 1.2998 mL |
Impurity F of Calcipotriol Related Classifications
HY-15265 Related Classifications
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