MC 1046
Based on 1 publication(s) in Google Scholar
MC 1046 (Impurity A of Calcipotriol) is a hepatic metabolite and an impurity of Calcipotriol (HY-10001). MC 1046 induces differentiation of histiocytic lymphoma cells. MC 1046 can be used for the research of histiocytic lymphoma.
For research use only. We do not sell to patients.
- Purity: 91.48%
- CAS No.: 126860-83-1
- Formula: C27H38O3
- Molecular Weight:410.59
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Storage:
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MC 1046
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Biological Activity
MC 1046 (96 h) shows no measurable proliferation inhibition at concentrations up to 1.0×10-7 M and shows a differentiation-inducing concentration of 1.0×10-7 M in U 937 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human histiocytic lymphoma U 937 cells
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Concentration:1.0×10-7 M
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Incubation Time:96 h
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Result:Did not inhibit U 937 cell proliferation at the highest tested concentration of 1.0×10-7 M, resulting in an IC50 >1.0×10-7 M.
Induced cell differentiation at 1.0×10-7 M.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 126860-83-1
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Appearance Solid
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Molecular Weight 410.59
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Formula C27H38O3
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Color Off-white to yellow
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SMILES
C[C@]1(CCC/2)C(C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C)CC[C@@H]1[C@H](C)/C=C/C(C4CC4)=O
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Synonyms
Impurity A of Calcipotriol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Steroid Biochem Mol Biol
Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells. [Abstract]2019 Apr:188:172-184. PMID: 30562554
Solvent & Solubility
DMSO : 50 mg/mL (121.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kissmeyer AM, et al. Calcipotriol (MC 903): pharmacokinetics in rats and biological activities of metabolites. A comparative study with 1,25(OH)2D3. Biochem Pharmacol. 1991 Jun 1;41(11):1601-6. [Content Brief]
[2]. Crankshaw DL, et al. Effect of phenobarbital induction, charcoal treatment and storage on the spectral binding characteristics and NADPH-cytochrome P-450 reductase activity of hepatic microsomes. Biochem Pharmacol. 1990 Jan 15;39(2):393-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4355 mL | 12.1776 mL | 24.3552 mL | 60.8880 mL |
| 5 mM | 0.4871 mL | 2.4355 mL | 4.8710 mL | 12.1776 mL | |
| 10 mM | 0.2436 mL | 1.2178 mL | 2.4355 mL | 6.0888 mL | |
| 15 mM | 0.1624 mL | 0.8118 mL | 1.6237 mL | 4.0592 mL | |
| 20 mM | 0.1218 mL | 0.6089 mL | 1.2178 mL | 3.0444 mL | |
| 25 mM | 0.0974 mL | 0.4871 mL | 0.9742 mL | 2.4355 mL | |
| 30 mM | 0.0812 mL | 0.4059 mL | 0.8118 mL | 2.0296 mL | |
| 40 mM | 0.0609 mL | 0.3044 mL | 0.6089 mL | 1.5222 mL | |
| 50 mM | 0.0487 mL | 0.2436 mL | 0.4871 mL | 1.2178 mL | |
| 60 mM | 0.0406 mL | 0.2030 mL | 0.4059 mL | 1.0148 mL | |
| 80 mM | 0.0304 mL | 0.1522 mL | 0.3044 mL | 0.7611 mL | |
| 100 mM | 0.0244 mL | 0.1218 mL | 0.2436 mL | 0.6089 mL |
MC 1046 Related Classifications
HY-15264 Related Classifications
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