2. Signaling Pathways
  3. Cytoskeleton
  4. Collagen

Collagen

Collagen

Collagens are the most abundant proteins in mammals. The collagen family comprises 28 members that contain at least one triple-helical domain. Beyond the existence of 28 collagen types, further diversity occurs in the collagen family because of the existence of several molecular isoforms for the same collagen type (e.g., collagens IV and VI) and of hybrid isoforms comprised of a chains belonging to two different collagen types (type V/XI molecules). Collagens are deposited in the extracellular matrix where most of them form supramolecular assemblies. Four collagens are type II membrane proteins that also exist in a soluble form released from the cell surface by shedding. Collagens play structural roles and contribute to mechanical properties, organization, and shape of tissues. They interact with cells via several receptor families and regulate their proliferation, migration, and differentiation[1].

Collagen Related Products (74):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-176194
    Antifibrotic agent 1
    		Chemical
    Antifibrotic agent 1 is an orally active anti-idiopathic pulmonary fibrosis (IPF) agent. Antifibrotic agent 1 effectively attenuates IPF-related processes, including TGF-β induced EMT and FMT processes, as well as pro-fibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α and Src family kinases (SFKs), while sparing VEGFRs, FGFRs and Abl to minimize off-target toxicity. Antifibrotic agent 1 has potent anti-fibrotic activity in Bleomycin (BLM) (HY-108345)-induced pulmonary fibrosis mice model.
    Antifibrotic agent 1
  • HY-P11827
    C11 peptide-1
    		Inhibitor
    C11 peptide-1 is an antifibrotic agent that binds directly to Collagen I. C11 peptide-1 physically disrupts Collagen I interaction with Lumican. C11 peptide-1 reduces inflammatory infiltration and inhibits the ERK1/2 and Smad2/3 signaling pathways. C11 peptide-1 can be used for the research of liver fibrosis.
    C11 peptide-1
  • HY-N11736
    12-O-Tiglyl-phorbol 13-dodecanoate
    		Inhibitor
    12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis.
    12-O-Tiglyl-phorbol 13-dodecanoate
  • HY-P11656
    α-Neoendorphin (porcine)
    		Modulator
    α-Neoendorphin porcine is a peptide. α-Neoendorphin porcine effectively alleviates UVB-induced skin photoaging via activating mTOR-Beclin-1-mediated autophagy, reducing UVB-triggered ROS production, inhibiting the MAPK pathway and MMP activity, and promoting type I procollagen synthesis. α-Neoendorphin porcine exerts anti-aging and anti-wrinkle effects on skin cells. α-Neoendorphin porcine can be used in studies related to skin photoaging.
    α-Neoendorphin (porcine)
  • HY-126956
    Porphyra 334
    		Activator
    Porphyra 334 is a carnosine-like amino acid and a natural photoprotective agent and antioxidant. Porphyra-334 exerts its photoprotective effects by scavenging ROS, inhibiting the expression and activity of MMP-1/8, and promoting the synthesis of collagen and elastin. Porphyra 334 effectively inhibits linoleic acid oxidation induced by alkyl radicals (AAPH) and singlet oxygen. Porphyra 334 has anti-obesity potential by inhibiting the expression of PPARγ2 and C/EBPα. Porphyra 334 protects cells against UV-induced DNA damage and apoptosis by inhibiting the activation of caspase-3.
    Porphyra 334
  • HY-P11447
    COLIV-peptide
    COLIV-peptide is a type of specific binding peptide that can recognize and bind to Collagen Ⅳ, a key non-cellular component in atherosclerotic plaques. COLIV-peptide can be used for the study of atherosclerotic.
    COLIV-peptide
  • HY-Y0775R
    1-Bromo-2,5-pyrrolidinedione (Standard)
    		Ligand
    1-Bromo-2,5-pyrrolidinedione (Standard) is the analytical standard of 1-Bromo-2,5-pyrrolidinedione (HY-Y0775). This product is intended for research and analytical applications. 1-Bromo-2,5-pyrrolidinedione is a collagen protein ligand in docking experiments. 1-Bromo-2,5-pyrrolidinedione can be used to study wound healing-related diseases.
    1-Bromo-2,5-pyrrolidinedione (Standard)
  • HY-148854
    L-Ascorbate sulfate disodium
    		Activator
    L-Ascorbate-2-sulfate disodium (page 46) is a pharmacologically acceptable salt of the L-Ascorbic acid (HY-B0166G) derivative. L-Ascorbate-2-sulfate disodium stimulates collagen synthesis and possess skin-care functions including an elimination function of active oxygen.
    L-Ascorbate sulfate disodium
  • HY-108681R
    680C91 (Standard)
    		Inhibitor
    680C91 (Standard) is the analytical standard of 680C91 (HY-108681). This product is intended for research and analytical applications. 680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a Ki of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease.
    680C91 (Standard)
  • HY-W404758
    Calcium glucoheptonate
    		Activator
    Calcium glucoheptonate is a highly water-soluble calcium supplement. Calcium glucoheptonate can increase the proliferation rate and Calcium intake of MG-63 cells and increase the activity of alkaline phosphatase (ALP). Calcium glucoheptonate can upregulate the expression of osteogenic-related genes and proteins,such as collagen-1, osteocalcin and osteocalcin. Calcium glucoheptonate can be used for the researches of osteoporosis and hypocalcemia.
    Calcium glucoheptonate
  • HY-174313
    Antibacterial agent 284
    		Inhibitor
    Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC50: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research.
    Antibacterial agent 284
  • HY-19017B
    Fenclozine dimaleate
    		Inhibitor
    Fenclozine dimaleate is a non-steroidal antiinflammatory agent.
    Fenclozine dimaleate
  • HY-W273690
    Pentifylline
    		Inhibitor 99.23%
    Pentifylline (1-Hexyltheobromine; Hexyltheobromine), PTX (HY-B0715) precursor compound, is a vasodilator. Pentifylline decreases procollagen levels and inhibits collagen production. Pentifylline reduces functional nuclear NF-1 to suppress procollagen gene transcription.
    Pentifylline
  • HY-167201
    2ccPA
    		Inhibitor
    2ccPA is a Cyclic phosphatidic acid derivative. 2ccPA decreases ECM expression, increases the intracellular cAMP levels. 2ccPA decreases the protein expression levels of type I collagen, CCN2 and αSMA. 2ccPA has inhibitory effects on the progression of skin fibrosis by abrogating ECM production from activated skin fibroblasts.
    2ccPA