α-Neoendorphin (porcine)
α-Neoendorphin porcine is a peptide. α-Neoendorphin porcine effectively alleviates UVB-induced skin photoaging via activating mTOR-Beclin-1-mediated autophagy, reducing UVB-triggered ROS production, inhibiting the MAPK pathway and MMP activity, and promoting type I procollagen synthesis. α-Neoendorphin porcine exerts anti-aging and anti-wrinkle effects on skin cells. α-Neoendorphin porcine can be used in studies related to skin photoaging.
For research use only. We do not sell to patients.
- CAS No.: 77739-20-9
- Formula: C60H89N15O13
- Molecular Weight:1228.44
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
α-Neoendorphin porcine (5 μg/mL; 15-30 min) activates autophagy in Hs68 cells by inhibiting the mTOR signaling pathway and upregulating the expression of autophagy-related proteins[1].
α-Neoendorphin porcine (0-20 μg/mL; 48 h) inhibits UVB-induced intracellular ROS production in Hs68 cells, reduces the levels of UVB-induced senescence-related proteins (p-ERK, p-p38, p-JNK) and the activities of MMP-2 and MMP-9 in cells[1].
α-Neoendorphin porcine (0.5-20 μg/mL; 48 h) attenuates UVB-induced inhibition of type I procollagen production in Hs68 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Hs68 human dermal fibroblasts
-
Concentration:5 μg/mL
-
Incubation Time:15 min; 30 min
-
Result:Decreased the levels of p-mTOR and p-p70S6K and increased the levels of mTOR, p70S6K, Beclin-1, Atg5-Atg12, and LC3-II after 30 min of treatment.
Chemical Information
-
CAS No. 77739-20-9
-
Molecular Weight 1228.44
-
Formula C60H89N15O13
-
Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys
-
Sequence Shortening
YGGFLRKYPK
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Neoendorphin (porcine) Related Classifications
HY-P11656 Related Classifications
Powered by Bioz