2. PI3K/Akt/mTOR Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB MAPK/ERK Pathway Cell Cycle/DNA Damage Cytoskeleton
  3. mTOR Beclin1 Autophagy Atg8/LC3 Reactive Oxygen Species (ROS) MMP p38 MAPK PERK JNK Collagen
  4. α-Neoendorphin (porcine)

α-Neoendorphin porcine is a peptide. α-Neoendorphin porcine effectively alleviates UVB-induced skin photoaging via activating mTOR-Beclin-1-mediated autophagy, reducing UVB-triggered ROS production, inhibiting the MAPK pathway and MMP activity, and promoting type I procollagen synthesis. α-Neoendorphin porcine exerts anti-aging and anti-wrinkle effects on skin cells. α-Neoendorphin porcine can be used in studies related to skin photoaging.

For research use only. We do not sell to patients.

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α-Neoendorphin (porcine)

α-Neoendorphin (porcine) Chemical Structure

CAS No. : 77739-20-9

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α-Neoendorphin (porcine) Related Antibodies

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Description

α-Neoendorphin porcine is a peptide. α-Neoendorphin porcine effectively alleviates UVB-induced skin photoaging via activating mTOR-Beclin-1-mediated autophagy, reducing UVB-triggered ROS production, inhibiting the MAPK pathway and MMP activity, and promoting type I procollagen synthesis. α-Neoendorphin porcine exerts anti-aging and anti-wrinkle effects on skin cells. α-Neoendorphin porcine can be used in studies related to skin photoaging[1].

In Vitro

α-Neoendorphin porcine (5 μg/mL; 15-30 min) activates autophagy in Hs68 cells by inhibiting the mTOR signaling pathway and upregulating the expression of autophagy-related proteins[1].
α-Neoendorphin porcine (0-20 μg/mL; 48 h) inhibits UVB-induced intracellular ROS production in Hs68 cells, reduces the levels of UVB-induced senescence-related proteins (p-ERK, p-p38, p-JNK) and the activities of MMP-2 and MMP-9 in cells[1].
α-Neoendorphin porcine (0.5-20 μg/mL; 48 h) attenuates UVB-induced inhibition of type I procollagen production in Hs68 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Neoendorphin (porcine) Related Antibodies

Western Blot Analysis[1]

Cell Line: Hs68 human dermal fibroblasts
Concentration: 5 μg/mL
Incubation Time: 15 min; 30 min
Result: Decreased the levels of p-mTOR and p-p70S6K and increased the levels of mTOR, p70S6K, Beclin-1, Atg5-Atg12, and LC3-II after 30 min of treatment.
Molecular Weight

1228.44

Formula

C60H89N15O13
CAS No.
Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys
Sequence Shortening

YGGFLRKYPK
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Room temperature in continental US; may vary elsewhere.
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References
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α-Neoendorphin (porcine) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Neoendorphin (porcine)77739-20-9mTORBeclin1AutophagyAtg8/LC3Reactive Oxygen Species (ROS)MMPp38 MAPKPERKJNKCollagenMammalian target of RapamycinAtg6Autophagy-related 8Matrix metalloproteinasesProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasec-Jun N-terminal kinasereactive oxygen speciesUVBskin photoaginghuman dermal fibroblast cellsautophagyBeclin-1Hs68Inhibitorinhibitorinhibit

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