2. Signaling Pathways
  3. Others
  4. Drug Derivative

Drug Derivative

Drug derivative

Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.

Drug Derivative Related Products (3819):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137318
    BM 15766 sulfate
    		99.43%
    BM 15766 sulfate is an inhibitor of 7-dehydrocholesterol δ7-reductase and reduces plasma cholesterol levels. BM 15766 sulfate is a hypolipidemic agent.
    BM 15766 sulfate
  • HY-W069604
    Thalidomide-5-Br
    		98.92%
    Thalidomide-5-Br (compound 4) is a compound with a bromodomain. Thalidomide-5-Br can be used in the research of inflammation, tumor and neurology.
    Thalidomide-5-Br
  • HY-148971A
    PtdIns-(345)-P3 (12-dipalmitoyl) sodium
    		98.0%
    PtdIns-(345)-P3 (12-dipalmitoyl) sodium (Phosphatidylinositol tris-3,4,5-phosphate, 1,2-dipalmitoyl sodium) is a phosphatidylinositol 3,4,5-trisphosphate (PIP3) analog. PtdIns-(345)-P3 (12-dipalmitoyl) sodium can be incorporated in liposomes establish a backdrop of membrane phospholipids that closely mirrors in vivo conditions.
    PtdIns-(345)-P3 (12-dipalmitoyl) sodium
  • HY-N10991
    Crocetin dialdehyde
    		99.75%
    Crocetin dialdehyde is a non-volatile apocarotenoid obtained by the action of the plastidic enzyme CCD2 over the carotenoid zeaxanthin in saffron. Crocetin dialdehyde can be converted into Crocetin (HY-N2072) by aldehyde dehydrogenases (ALDHs). Crocetin dialdehyde has no effect on the liver in mice.
    Crocetin dialdehyde
  • HY-165772
    10-Hydroxy-12(Z)-octadecenoic acid
    		99.82%
    10-Hydroxy-12(Z)-octadecenoic acid is a hydroxy-unsaturated fatty acid that can be found in microorganisms such as lactic acid bacteria.
    10-Hydroxy-12(Z)-octadecenoic acid
  • HY-400882
    Tosylate-DPA-714
    		98.78%
    Tosylate-DPA-714 is a GMP-grade precursor for the radiosynthesis of DPA-714 (HY-122607). It crosses the blood-brain barrier and exhibits steroidogenic activity. DPA-714 is a specific ligand for the 18 kDa translocator protein (TSPO) with a Ki of 7.0 nM. Tosylate-DPA-714 is safe and does not bind to central benzodiazepine receptors (benzodiazepine receptor). As a radiolabeling precursor, Tosylate-DPA-714 reacts with 18F via nucleophilic aliphatic substitution to form 18F-DPA-714, enabling specific targeted binding to TSPO. 18F-DPA-714 accurately reflects the level of neuroinflammation mediated by microglial activation, and is used for PET molecular imaging of neurological diseases such as Alzheimer's disease and multiple sclerosis.
    Tosylate-DPA-714
  • HY-78869
    Mutated EGFR-IN-1
    		99.90%
    Mutated EGFR-IN-1 (Osimertinib analog) (Intermediate 168) is a structural analog of Osimertinib (HY-15772) and can be used as a pharmaceutical intermediate for EGFR inhibitors.
    Mutated EGFR-IN-1
  • HY-117109
    Amino Tadalafil
    		98.89%
    Amino Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor analog and tadalafil structural analog. Amino Tadalafil can be specifically detected by anti-tadalafil polyclonal antibodies, with a cross-reactivity of 105.2% with tadalafil. Amino Tadalafil can be incorporated into dietary supplements.
    Amino Tadalafil
  • HY-B0326
    Alibendol
    		99.94%
    Alibendol can be taken orally. It has anti-spasmodic properties and promotes bile secretion, making it useful for research on digestive system issues like indigestion, nausea, vomiting, and constipation.
    Alibendol
  • HY-136506
    NUC-7738
    NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer.
    NUC-7738
  • HY-W004292
    1-Undecanol
    		99.79%
    1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps.
    1-Undecanol
  • HY-N6880
    Rabdosiin
    		99.55%
    Rabdosiin ((+)-Rabdosiin) is a Caffeic acid (HY-N0172) tetramer. Rabdosiin can be isolated from Macrotomia euchroma.
    Rabdosiin
  • HY-W013827
    Isomannide
    		99.93%
    Isomannide (1,4:3,6-Dianhydromannitol) is a common intermediate compound and derivative of Isosorbide (HY-B1469). Some derivatives of isomannide have potent inhibitory effects on KLK5 and KLK7. Isomannide can be used in the research of HCV infection and KLK5/KLK7-related diseases.
    Isomannide
  • HY-172741
    Dioctanoyl PI(3,5)P2 sodium
    		98.7%
    Dioctanoyl PI(3,5)P2 sodium is a synthetic analog of PI(3,5)P2 (a natural phosphatidylinositol). Phosphatidylinositol phosphates (PIPs) are intracellular amphiphilic molecules implicated in numerous cellular responses including growth, division, movement, differentiation, neuro-exocytosis, and survival.
    Dioctanoyl PI(3,5)P2 sodium
  • HY-125904
    4-Hydroxyretinoic acid
    4-Hydroxyretinoic acid (4-HRA) is a derivative of Retinoic acid (HY-14649). 4-Hydroxyretinoic acid is formed via the catalysis of retinol by cytochrome P-450 isoenzymes. 4-Hydroxyretinoic acid also serves as a substrate for UDP-glucuronosyltransferase (s) and recombinant UGT2B7. 4-Hydroxyretinoic acid binds to the nuclear receptor RAR (Retinoic Acid Receptor), activates RAR and RXR-alpha, subsequently regulates gene expression and cell differentiation, and induces cancer cell apoptosis (Apoptosis). 4-Hydroxyretinoic acid also participates in multiple physiological processes such as immunoregulation, neuroprotection and antioxidation.
    4-Hydroxyretinoic acid
  • HY-139093A
    Paracetamol-cysteine TFA
    		99.25%
    Paracetamol-cysteine (TFA) is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (HY-66005).
    Paracetamol-cysteine TFA
  • HY-131501
    Menaquinone 9
    		98.0%
    Menaquinone 9 is a vitamin K2 (HY-109569) analog. Menaquinone 9 acts as a prothrombogenic agent and functional electron transfer component in nitrate reductase.
    Menaquinone 9
  • HY-B2212
    Dibenzoyl Thiamine
    		99.83%
    Dibenzoyl Thiamine (Bentiamine), a derivative of thiamine, is rapidly absorbed into the body and converted to thiamine.
    Dibenzoyl Thiamine
  • HY-14942
    Berubicin
    Berubicin (RTA 744 free base) is a Doxorubicin (HY-15142A) analog that can cross the blood-brain barrier. Berubicin inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). Berubicin exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. Berubicin can be used in the study of tumors related to the nervous system.
    Berubicin
  • HY-101701
    Hepronicate
    		99.95%
    Hepronicate, a nicotinic acid derivative, is a peripheral vasodilator with blood lipid lowering action. Hepronicate works by improving peripheral circulatory disturbances.
    Hepronicate