Isomannide
Based on 1 Customer Validation
Isomannide (1,4:3,6-Dianhydromannitol) is a cyclic diol and a derivative of Isosorbide (HY-B1469). Isomannide serves as a starting material for chiral solubilizers and a linker group for novel bacterial topoisomerase inhibitors (NBTIs). Isomannide is also used in the synthesis of biocompatible polymers.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 641-74-7
- Formula: C6H10O4
- Molecular Weight:146.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Isomannide undergoes monotosylation with p-toluenesulfonyl chloride in pyridine[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 641-74-7
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Appearance Solid
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Molecular Weight 146.14
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Formula C6H10O4
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Color White to off-white
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SMILES
O[C@H]1[C@]2([H])[C@@](OC1)([H])[C@@H](CO2)O
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Synonyms
1,4:3,6-Dianhydromannitol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (684.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5.83 mg/mL (39.89 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (34.21 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (34.21 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Balzano F, et al. Renewable Resources for Enantiodiscrimination: Chiral Solvating Agents for NMR Spectroscopy from Isomannide and Isosorbide. The Journal of organic chemistry. 2022 Oct 07;87(19):12698-12709. [Content Brief]
[2]. Okumu A, et al. Novel bacterial topoisomerase inhibitors derived from isomannide. European journal of medicinal chemistry. 2020 Aug 01;199:112324. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.8428 mL | 34.2138 mL | 68.4275 mL | 171.0688 mL |
| 5 mM | 1.3686 mL | 6.8428 mL | 13.6855 mL | 34.2138 mL | |
| 10 mM | 0.6843 mL | 3.4214 mL | 6.8428 mL | 17.1069 mL | |
| 15 mM | 0.4562 mL | 2.2809 mL | 4.5618 mL | 11.4046 mL | |
| 20 mM | 0.3421 mL | 1.7107 mL | 3.4214 mL | 8.5534 mL | |
| 25 mM | 0.2737 mL | 1.3686 mL | 2.7371 mL | 6.8428 mL | |
| 30 mM | 0.2281 mL | 1.1405 mL | 2.2809 mL | 5.7023 mL | |
| DMSO | 40 mM | 0.1711 mL | 0.8553 mL | 1.7107 mL | 4.2767 mL |
| 50 mM | 0.1369 mL | 0.6843 mL | 1.3686 mL | 3.4214 mL | |
| 60 mM | 0.1140 mL | 0.5702 mL | 1.1405 mL | 2.8511 mL | |
| 80 mM | 0.0855 mL | 0.4277 mL | 0.8553 mL | 2.1384 mL | |
| 100 mM | 0.0684 mL | 0.3421 mL | 0.6843 mL | 1.7107 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Isomannide Related Classifications
HY-W013827 Related Classifications
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- Isomannide
- 641-74-7
- 1,4:3,6-Dianhydromannitol
- Biochemical Assay Reagents
- Drug Derivative
- Drug Intermediate
- Gram-positive pathogens
- fluoroquinolone-resistant MRSA
- hERG
- para-toluenesulfonyl chloride
- methicillin-resistant staphylococcus aureus infection
- cystic fibrosis-associated bacterial infection
- pyridine
- Inhibitor
- inhibitor
- inhibit