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Berubicin  (Synonyms: RTA 744 free base; WP 744 free base; WP 769)

Cat. No.: HY-14942
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Berubicin (RTA 744 free base; WP 744) is a 4'-O-benzyldoxorubicin that inhibits P-gp and MRP1-mediated efflux and has anticancer activity. Berubicin inhibits glioblastoma multiforme (GBM) and exhibits cytotoxicity. Berubicin has poor bioavailability in mice.

For research use only. We do not sell to patients.

Berubicin Chemical Structure

Berubicin Chemical Structure

CAS No. : 677017-23-1

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1 mg USD 245 In-stock
5 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Berubicin:

Berubicin Related Antibodies

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Description

Berubicin (RTA 744 free base; WP 744) is a 4'-O-benzyldoxorubicin that inhibits P-gp and MRP1-mediated efflux and has anticancer activity. Berubicin inhibits glioblastoma multiforme (GBM) and exhibits cytotoxicity. Berubicin has poor bioavailability in mice[1].

Molecular Weight

633.64

Formula

C34H35NO11
CAS No.
Appearance

Solid

Color

Purple to purplish red

SMILES

OC1=C2C([C@@]([H])(O[C@H]3C[C@H](N)[C@H](OCC4=CC=CC=C4)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)=C(O)C5=C1C(C6=CC=CC(OC)=C6C5=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (157.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5782 mL 7.8909 mL 15.7818 mL
5 mM 0.3156 mL 1.5782 mL 3.1564 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5782 mL 7.8909 mL 15.7818 mL 39.4546 mL
5 mM 0.3156 mL 1.5782 mL 3.1564 mL 7.8909 mL
10 mM 0.1578 mL 0.7891 mL 1.5782 mL 3.9455 mL
15 mM 0.1052 mL 0.5261 mL 1.0521 mL 2.6303 mL
20 mM 0.0789 mL 0.3945 mL 0.7891 mL 1.9727 mL
25 mM 0.0631 mL 0.3156 mL 0.6313 mL 1.5782 mL
30 mM 0.0526 mL 0.2630 mL 0.5261 mL 1.3152 mL
40 mM 0.0395 mL 0.1973 mL 0.3945 mL 0.9864 mL
50 mM 0.0316 mL 0.1578 mL 0.3156 mL 0.7891 mL
60 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6576 mL
80 mM 0.0197 mL 0.0986 mL 0.1973 mL 0.4932 mL
100 mM 0.0158 mL 0.0789 mL 0.1578 mL 0.3945 mL
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Berubicin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Berubicin677017-23-1RTA 744WP 744 WP 769RTA744RTA-744WP744WP-744WP769WP 769WP-769OthersInhibitorinhibitorinhibit

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