BM 15766 sulfate
Based on 1 Customer Validation
BM 15766 sulfate is an inhibitor of 7-dehydrocholesterol δ7-reductase and reduces plasma cholesterol levels. BM 15766 sulfate is a hypolipidemic agent.
For research use only. We do not sell to patients.
- Purity: 99.43%
- CAS No.: 86621-94-5
- Formula: C22H27ClN2O6S
- Molecular Weight:482.98
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
500 nM
Compound: BM 15.766 sulfate
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Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 24 hrs GC/MS analysis
Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 24 hrs GC/MS analysis
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[PMID: 22882119] |
Chemical Information
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CAS No. 86621-94-5
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Appearance Solid
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Molecular Weight 482.98
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Formula C22H27ClN2O6S
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(CCN2CCN(C/C=C/C3=CC=C(Cl)C=C3)CC2)C=C1.O=S(O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (207.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Baumgart E, et al. Proliferation of peroxisomes without simultaneous induction of the peroxisomal fatty acid beta-oxidation. FEBS Lett. 1990 May 7;264(1):5-9. [Content Brief]
[2]. Honda, et al. Regulation of the last two enzymatic reactions in cholesterol biosynthesis in rats: effects of BM 15.766, cholesterol, cholic acid, lovastatin, and their combinations. Hepatology. 1996 Aug;24(2):435-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0705 mL | 10.3524 mL | 20.7048 mL | 51.7620 mL |
| 5 mM | 0.4141 mL | 2.0705 mL | 4.1410 mL | 10.3524 mL | |
| 10 mM | 0.2070 mL | 1.0352 mL | 2.0705 mL | 5.1762 mL | |
| 15 mM | 0.1380 mL | 0.6902 mL | 1.3803 mL | 3.4508 mL | |
| 20 mM | 0.1035 mL | 0.5176 mL | 1.0352 mL | 2.5881 mL | |
| 25 mM | 0.0828 mL | 0.4141 mL | 0.8282 mL | 2.0705 mL | |
| 30 mM | 0.0690 mL | 0.3451 mL | 0.6902 mL | 1.7254 mL | |
| 40 mM | 0.0518 mL | 0.2588 mL | 0.5176 mL | 1.2940 mL | |
| 50 mM | 0.0414 mL | 0.2070 mL | 0.4141 mL | 1.0352 mL | |
| 60 mM | 0.0345 mL | 0.1725 mL | 0.3451 mL | 0.8627 mL | |
| 80 mM | 0.0259 mL | 0.1294 mL | 0.2588 mL | 0.6470 mL | |
| 100 mM | 0.0207 mL | 0.1035 mL | 0.2070 mL | 0.5176 mL |
BM 15766 sulfate Related Classifications
HY-137318 Related Classifications
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