Proliferation of peroxisomes without simultaneous induction of the peroxisomal fatty acid beta-oxidation

  • FEBS Lett. 1990 May 7;264(1):5-9. doi: 10.1016/0014-5793(90)80750-d.
E Baumgart  1 ,  A Völkl ,  J Pill ,  H D Fahimi
Affiliations
  • 1. Department of Anatomy and Cell Biology II, University of Heidelberg, FRG.
PMID: 2338145 DOI: 10.1016/0014-5793(90)80750-d
Abstract

Marked proliferation of rat hepatic peroxisomes is observed after treatment with a new potent hypolipidemic drug BM 15766, as well as after bezafibrate. Whereas the relative specific activity of the peroxisomal fatty acid beta-oxidation system is not affected by BM 15766 it is significantly increased after bezafibrate. This is also confirmed by immunoblot analysis of individual beta-oxidation Enzymes in highly purified peroxisome fractions. These observations suggest that peroxisome proliferation and the induction of the fatty acid beta-oxidation are regulated separately.

Products