Mutated EGFR-IN-1
Based on 1 publication(s) in Google Scholar
Mutated EGFR-IN-1 (Osimertinib analog) (Intermediate 168) is a structural analog of Osimertinib (HY-15772) and can be used as a pharmaceutical intermediate for EGFR inhibitors.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 1421372-66-8
- Formula: C25H31N7O
- Molecular Weight:445.56
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-L001V
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Posttranslational Modification Library
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Publications Citing Use of MedChemExpress (MCE) Mutated EGFR-IN-1
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Biological Activity
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.
EGFR inhibitors specifically block epidermal growth factor receptors, thereby inhibiting tumor proliferation by cutting off growth signals of tumor cells. They can be used to study malignant tumors such as non-small cell lung cancer, pancreatic cancer, and colorectal cancer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1421372-66-8
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Appearance Solid
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Molecular Weight 445.56
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Formula C25H31N7O
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Color Pale purple to khaki
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SMILES
NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C
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Synonyms
Osimertinib analog
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : ≥ 75 mg/mL (168.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2444 mL | 11.2218 mL | 22.4437 mL | 56.1092 mL |
| 5 mM | 0.4489 mL | 2.2444 mL | 4.4887 mL | 11.2218 mL | |
| 10 mM | 0.2244 mL | 1.1222 mL | 2.2444 mL | 5.6109 mL | |
| 15 mM | 0.1496 mL | 0.7481 mL | 1.4962 mL | 3.7406 mL | |
| 20 mM | 0.1122 mL | 0.5611 mL | 1.1222 mL | 2.8055 mL | |
| 25 mM | 0.0898 mL | 0.4489 mL | 0.8977 mL | 2.2444 mL | |
| 30 mM | 0.0748 mL | 0.3741 mL | 0.7481 mL | 1.8703 mL | |
| 40 mM | 0.0561 mL | 0.2805 mL | 0.5611 mL | 1.4027 mL | |
| 50 mM | 0.0449 mL | 0.2244 mL | 0.4489 mL | 1.1222 mL | |
| 60 mM | 0.0374 mL | 0.1870 mL | 0.3741 mL | 0.9352 mL | |
| 80 mM | 0.0281 mL | 0.1403 mL | 0.2805 mL | 0.7014 mL | |
| 100 mM | 0.0224 mL | 0.1122 mL | 0.2244 mL | 0.5611 mL |
Mutated EGFR-IN-1 Related Classifications
HY-78869 Related Classifications
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