1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. Mutated EGFR-IN-1

Mutated EGFR-IN-1 (Synonyms: Osimertinib analog)

Cat. No.: HY-78869 Purity: 99.88%
Handling Instructions

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.

For research use only. We do not sell to patients.

Mutated EGFR-IN-1 Chemical Structure

Mutated EGFR-IN-1 Chemical Structure

CAS No. : 1421372-66-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. IC50 value: Target: Mutated EGFR inhibitor More information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer.

IC50 & Target[1]

EGFRL858R

 

EGFRExon 19 deletion/T790M

 

EGFRT790M

 

Molecular Weight

445.56

Formula

C₂₅H₃₁N₇O

CAS No.

1421372-66-8

SMILES

NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 75 mg/mL (168.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2444 mL 11.2218 mL 22.4437 mL
5 mM 0.4489 mL 2.2444 mL 4.4887 mL
10 mM 0.2244 mL 1.1222 mL 2.2444 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.88%

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Keywords:

Mutated EGFR-IN-1Osimertinib analogEGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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Mutated EGFR-IN-1
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