2. Signaling Pathways
  3. Others
  4. Drug Isomer

Drug Isomer

Drug Isomer

Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.

Drug Isomer Related Products (434):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-153321A
    (R,R)-Bexobrutideg
    		98.83%
    (R,R)-Bexobrutideg is the (R,R)-enantiomer of Bexobrutideg (HY-153321). Bexobrutideg (NX-5948) is an orally active PROTAC that induces specific BTK protein degradation via a cereblon E3 ligase (CRBN) complex without degrading other cereblon neo substrates. Bexobrutideg mediates potent anti-inflammatory activity through BTK degradation, thereby inhibiting B cell activation. Bexobrutideg exhibits potent tumor growth inhibition in TMD8 xenograft models containing wild-type BTK or BTKi resistance mutations. Bexobrutideg is effective in a mouse model of collagen-induced arthritis (CIA). Bexobrutideg can cross the blood-brain barrier. NX-5948 consists of a target protein ligand, a linker, and a VHL E3 ubiquitin ligase (Red: BTK ligand (HY-170324); Blue: CRBN ligand (HY-171893); Black: linker).
    (R,R)-Bexobrutideg
  • HY-156438A
    (S)-Ruvonoflast
    		99.65%
    (S)-Ruvonoflast ((S)-NT-0796) is the S-isomer of Ruvonoflast (HY-156438). Ruvonoflast (NT-0796) is an orally active, selective, centrally nervous system-transporting NLRP3 inflammasome inhibitor.
    (S)-Ruvonoflast
  • HY-111372B
    (R)-Finerenone
    (R)-Finerenone ((R)-BAY 94-8862) is the R-isomer of Finerenone (HY-111372). Finerenone is a third-generation selective, orally active, non-steroidal mineralocorticoid receptor (MR) antagonist (IC50 = 18 nM). Compared with glucocorticoid receptors (GR), androgen receptors (AR), and progesterone receptors (AR), Finerenone shows good selectivity (> 500-fold). Finerenone has potential application prospects in studies of heart and kidney diseases, such as type 2 diabetes and chronic kidney disease.
    (R)-Finerenone
  • HY-158684A
    (4R,5S)-YX-02-030
    		99.63%
    (4R,5S)-YX-02-030 is an isomer of YX-02-030 (HY-158684). YX-02-030 is a PROTAC MDM2 degrader.
    (4R,5S)-YX-02-030
  • HY-169825
    (S)-PF-04995274
    (S)-PF-04995274 is a partial agonist of the 5-hydroxytryptamine receptor 4 (5-HT4R) and is an isomer of PF-04995274 (HY-18137).
    (S)-PF-04995274
  • HY-P2996A
    Nitrate Reductase, Arabidopsis thaliana
    Nitrate Reductase, Arabidopsis thaliana is the isomer of NAD(P)H-Nitrate reductase (HY-P2996). NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants，the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase.
    Nitrate Reductase, Arabidopsis thaliana
  • HY-113887A
    11β-Prostaglandin F1β
    		Control
    11β-Prostaglandin F1β (11β-PGF1β) is a stereoisomer of PGF1α with inverted C-9 and C-11 hydroxyl groups.
    11β-Prostaglandin F1β
  • HY-139553A
    (R)-Zunsemetinib
    		Control
    (R)-Zunsemetinib is the isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases.
    (R)-Zunsemetinib
  • HY-B1296B
    (R)-Promethazine
    (R)-Promethazine is the R-enantiomer of Promethazine (HY-B1296). Promethazine is an orally active histamine receptor antagonist. Promethazine is first-generation antihistamine of the phenothiazine family, shows strong sedative and weak antipsychotic effects.
    (R)-Promethazine
  • HY-15121A
    DL-Theanine
    DL-Theanine (DL-Glutamic acid γ-ethyl amide) is a natural compound showing tranquilizing effects in the brain.
    DL-Theanine
  • HY-W007880A
    (R)-D2PM hydrochloride
    (R)-D2PM ((R)-Diphenylprolinol) hydrochloride is an isomer of the psychoactive substance D2PM and a pyrrolidine analog.
    (R)-D2PM hydrochloride
  • HY-109854
    (S)-Lisofylline
    		99.89%
    (S)-Lisofylline ((S)-Lisophylline)) is a kind of lisofline (LSF) enantiomer with optical activity. (S)-Lisofylline can interconversion with pentoxifylline.
    (S)-Lisofylline
  • HY-162683A
    (R)-PHA533533
    (R)-PHA533533 is an inactive enantiomer (S)-PHA533533 (active enantiomer) (HY-162683). (S)-PHA533533 is a CDK2 inhibitor with antitumor activity.
    (R)-PHA533533
  • HY-175061
    2-MeOMC hydrochloride
    2-MeOMC hydrochloride is a positional isomer of Methedrone. 2-MeOMC hydrochloride has central nervous system stimulant activity.
    2-MeOMC hydrochloride
  • HY-N19703
    (+)-Hydrangenol monomethyl ether
    (+)-Hydrangenol monomethyl ether is a hydrangenol-monomethyl ether (+)-enantiomer found in axenic cultures of the liverwort Plagiochila adianthoides.
    (+)-Hydrangenol monomethyl ether
  • HY-123382
    GSK-1482160 (isomer)
    GSK-1482160 isomer is the isomer of GSK-1482160 (HY-19888). GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor (P2X7R) negative allosteric modulator with pIC50s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β. GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI).
    GSK-1482160 (isomer)
  • HY-76542AR
    5,6-trans-Vitamin D2 (Standard)
    5,6-trans-Vitamin D2 (Standard) is the analytical standard of 5,6-trans-Vitamin D2. This product is intended for research and analytical applications. 5,6-trans-Vitamin D2 is the isomer of Vitamin D2[1].
    5,6-trans-Vitamin D2 (Standard)
  • HY-107176
    (E)-Hyzetimibe
    (E)-Hyzetimibe ((E)-HS-25) (Compound I-1Z) is the trans isomer of Hyzetimibe (HY-107176A), a cholesterol-lowering agent. (E)-Hyzetimibe has cholesterol acyltransferase (ACTA) inhibitory activity, but its cholesterol-lowering effect is relatively weak. (E)-Hyzetimibe can inhibit the entry of hepatitis C virus (HCV) into host cells, and it has a synergistic effect when used in combination with interferon-α. (E)-Hyzetimibe can be used for the study of HCV infection.
    (E)-Hyzetimibe
  • HY-10121D
    rel-Asenapine hydrochloride
    rel-Asenapine (rel-Org 5222) hydrochloride is a relative configuration of Asenapine hydrochloride (HY-16567). Asenapine (Org 5222) hydrochloride, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine hydrochloride can be used in the research of schizophrenia and bipolar disorder.
    rel-Asenapine hydrochloride
  • HY-18500
    (βS)-β-Hydroxy-L-histidine hydrochloride
    (βS)-β-Hydroxy-L-histidine hydrochloride is a stereoisomer of β-hydroxyhistidine.
    (βS)-β-Hydroxy-L-histidine hydrochloride