GSK-1482160 (isomer)
GSK-1482160 isomer is the isomer of GSK-1482160 (HY-19888). GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor (P2X7R) negative allosteric modulator with pIC50s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β. GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI).
For research use only. We do not sell to patients.
- CAS No.: 1695551-19-9
- Formula: C14H14ClF3N2O2
- Molecular Weight:334.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1695551-19-9
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Molecular Weight 334.72
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Formula C14H14ClF3N2O2
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SMILES
ClC1=C(C(F)(F)F)C=CC=C1CN(C)C([C@@H]2CCC(N2)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK-1482160 (isomer) Related Classifications
HY-123382 Related Classifications
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