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Cat. No.: HY-162683A

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(R)-PHA533533

(R)-PHA533533 is an inactive enantiomer (S)-PHA533533 (active enantiomer) (HY-162683). (S)-PHA533533 is a CDK2 inhibitor with antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 437982-90-6
Formula: C₁₉H₂₂N₄O₂
Molecular Weight:338.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

(R)-PHA533533 Chemical Structure

CAS No.: 437982-90-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(R)-PHA533533 is an inactive enantiomer (S)-PHA533533 (active enantiomer) (HY-162683). (S)-PHA533533 is a CDK2 inhibitor with antitumor activity^[1].

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	12200 nM Compound: 12(table 2)	Inhibitory concentration towards human ovarian carcinoma cell line A2780 Inhibitory concentration towards human ovarian carcinoma cell line A2780	[PMID: 15828833]

Chemical Information

CAS No. 437982-90-6
Molecular Weight 338.40
Formula C₁₉H₂₂N₄O₂
SMILES

C[C@H](C1=CC=C(N2C(CCC2)=O)C=C1)C(NC3=NNC(C4CC4)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vihma H, et al. Ube3a unsilencer for the potential treatment of Angelman syndrome. Nat Commun. 2024 Jul 8;15(1):5558. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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(R)-PHA533533

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(R)-PHA533533 Related Classifications

HY-162683A Related Classifications