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  4. Fluorescent Dye

Fluorescent Dye

Fluorescence is a phenomenon of photoluminescence in luminescence. When an atom is irradiated by light, some electrons around the nucleus jump from their original orbitals to higher energy orbitals under the influence of light energy, i.e., from the ground state to the first or second excited single-line state, etc. Due to the instability of the first or second excited singlet state, the electron returns from the excited singlet state to the ground state accompanied by released energy, resulting in fluorescence.

Fluorescent dyes can be covalently bound or physically adsorbed in the structure of the substance. The fluorescence properties allow for the characterization, localization and quantitative analysis of the labeled object. Fluorescent dyes have shown great potential for the detection of proteins, nucleic acids, cells, and immunoassays, attributed to the advantages in non-radioactive contamination, simple experimental operation and easy observation.

Fluorescent dyes have penetrated many fields such as pharmacology, physiology, environmental science, and information science, as well as functional studies of proteins and drug screening.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-141729
    Biotin-NH-PSMA-617
    		98.77%
    Biotin-NH-PSMA-617 is a biotin-tagged PSMA-617. PSMA-617 is a small molecule targeting the prostate-specific membrane antigen (PSMA), which is directly expressed by the tumor cells .
    Biotin-NH-PSMA-617
  • HY-W040254
    Biotin-LC-LC-NHS
    		98.0%
    Biotin-LC-LC-NHS is a biotinylation reagent that contains an NHS moiety, which can react efficiently with primary amino (-NH2). Biotin-LC-LC-NHS enables simple and efficient biotinylation of antibodies, proteins, and any other primary amine-containing biomolecules in solution. Biotin-LC-LC-NHS can be used to biotinylate small molecules such as Paclitaxel (HY-B0015) for use in binding site characterization.
    Biotin-LC-LC-NHS
  • HY-DY1008
    Nile Red (solution)
    Nile Red (solution) is a lipophilic stain. Nile red has environment-sensitive fluorescence. Nile red is intensely fluorescent in a lipid-rich environment while it has minimal fluorescence in aqueous media. Nile red is an excellent vital stain for the detection of intracellular lipid droplets by fluorescence microscopy and flow cytof uorometry. Nile red stains intracellular lipid droplets red. The fluorescence wavelength is 559/635 nm.
    Solvent and concentration: DMSO: 1 mM
    Nile Red (solution)
  • HY-133527
    OG 488, SE
    OG 488, SE (Oregon green 488 succinimidyl ester), a fluorescent pH indicator, has many applications in biochemistry and neurosciences.
    OG 488, SE
  • HY-133884
    ICG-amine
    		98.34%
    ICG amine, as a near-infrared fluorescent probe, binds to amino acid residues without condensing agents. ICG is a tricarbocyanine dye.
    ICG-amine
  • HY-149618
    Cy5-PEG3-endo-BCN
    		98.40%
    Cy5-PEG3-endo-BCN is a derivative of the Cyanine 5 (Cy5) (HY-D0821) dye bearing 3 PEG units. Cy5-PEG3-endo-BCN contains the lyophilic bidentate macrocyclic ligand endo-BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, endo-BCN forms stable triazoles with azide-containing molecules under catalyst-free conditions.
    Cy5-PEG3-endo-BCN
  • HY-118159
    Diphenyl-1-pyrenylphosphine
    		98.56%
    Diphenyl-1-pyrenylphosphine (DPPP) is a functional organic molecule with both fluorescent properties and metal coordination ability, which is commonly used in materials and coordination chemistry research. Upon exposure to ultraviolet light, Diphenyl-1-pyrenylphosphine undergoes photoinduced phosphorus atom oxidation to form O-DPPP, triggering a transition from aggregation-induced emission (AIE) to aggregation-caused quenching (ACQ). Diphenyl-1-pyrenylphosphine reacts stoichiometrically with lipid hydroperoxides to produce fluorescent diphenyl-1-pyrenylphosphine oxide. Diphenyl-1-pyrenylphosphine can insert into cell membranes to monitor lipid peroxidation processes in living cells.
    Diphenyl-1-pyrenylphosphine
  • HY-D1457
    DND-189
    		99.78%
    DND-189, a low-pH fluorescent probe, is sensitive to neutral and low pH range. DND-189 can be used to measure the pH of acidic organelles.
    DND-189
  • HY-P4323A
    Boc-Gln-Arg-Arg-AMC acetate
    		99.25%
    Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal.
    Boc-Gln-Arg-Arg-AMC acetate
  • HY-D0194
    5(6)-Carboxy-2',7'-dichlorofluorescein
    		99.03%
    5(6)-Carboxy-2',7'-dichlorofluorescein is an ideal substrate for MRP2 vesicular transport assay, with excellent detection and transport properties.
    5(6)-Carboxy-2',7'-dichlorofluorescein
  • HY-D1703
    Oxazine 170 perchlorate
    		98.81%
    Oxazine 170 perchlorate is a laser dye with a wide excitation spectrum range (300−550 nm), which strongly absorbs light with a wavelength greater than 550 nm, and it emits fluorescence with a wavelength of about 645 nm.
    Oxazine 170 perchlorate
  • HY-D0031
    8-Aminopyrene-1,3,6-trisulfonic acid trisodium
    		99.75%
    8-Aminopyrene-1,3,6-trisulfonic acid trisodium (APTS) is an anionic fluorescent dye (excitation/emission: 425/503 nm in pH 7.4 PBS). The fluorescence intensity of 8-Aminopyrene-1,3,6-trisulfonic acid trisodium remains stable at pH 4-10. 8-Aminopyrene-1,3,6-trisulfonic acid trisodium retains its fluorescence properties when immobilized in a hydrogel by copolymerization. 8-Aminopyrene-1,3,6-trisulfonic acid trisodium can be used for glucose sensing.
    8-Aminopyrene-1,3,6-trisulfonic acid trisodium
  • HY-W027968
    Coumarin-3-carboxylic Acid
    		99.93%
    Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line.
    Coumarin-3-carboxylic Acid
  • HY-P2179
    MMP-1/MMP-9 Substrate, Fluorogenic
    		98.83%
    MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9.Ex/Em = 340/440 nm
    MMP-1/MMP-9 Substrate, Fluorogenic
  • HY-110334
    FFN 206 dihydrochloride
    		99.45%
    FFN 206 dihydrochloride, a fluorescent probe, is used as an excellent Vesicular Monoamine Transporter 2 (VMAT2) substrate with an apparent Km of 1.16 μM. FFN 206 dihydrochloride is capable of detecting VMAT2 activity in intact cells using fluorescence microscopy, with subcellular localization to VMAT2-expressing acidic compartments without apparent labeling of other organelles.
    FFN 206 dihydrochloride
  • HY-172163
    FITC-dextran sulfate (MW 4kDa)
    FITC-dextran sulfate, 4kDa is a sodium dextran sulfate labeled with FITC, with an average molecular weight of 4 kDa.
    FITC-dextran sulfate (MW 4kDa)
  • HY-W800705
    Tamra azide
    		98.97%
    Tamra azide is an azide-terminated fluorescent dye and click reaction partner. Tamra azide undergoes CuI-catalyzed cycloaddition click reaction with alkyne-functionalized nanodiamonds. After conjugation with nanodiamonds, Tamra azide serves as a fluorescent label that can be excited at a specific wavelength to exhibit characteristic luminescence (Ex/Em=555/580 nm).
    Tamra azide
  • HY-155640
    5-FAM maleimide
    		98.54%
    Maleimide-5’FAM is a fluorescein. Maleimide-5’FAM can be used for labeling non-transduced cells.
    5-FAM maleimide
  • HY-I0259
    8-Amino-2-naphthol
    		≥98.0%
    8-Amino-2-naphthol is a photoactive charge transfer compounds, which can be used as fluorescent probe. 8-Amino-2-naphthol undergoes excited-state proton transfer (ESPT) to form a zwitterion under acidic conditions, where the photoacidity of its hydroxyl group is regulated by the protonation state of the amino group, enabling pH to act as an on/off switch for photoacidity. 8-Amino-2-naphthol is also utilized as chiral organocatalyst.
    8-Amino-2-naphthol
  • HY-100335
    PCI-33380
    		98.0%
    PCI-33380 is a fluorescent probe ( (Ex=532 nm, Em=555 nm). PCI-33380 consists of a (BTK) inhibitor PCI-32765 (HY-10997) attaching with a Bodipy-FL fluorophore via a piperazine linker. PCI-33380 binds predominantly to Btk in B cell lysates with cell permeable activity. PCI-33380 can be used for imaging live cancer cells such as non-Hodgkin lymphoma research
    PCI-33380
Cat. No. Product Name / Synonyms Application Reactivity