Na+/H+ Exchanger (NHE)
Sodium/hydrogen Exchanger; Sodium-hydrogen Exchanger
Na+/H+ exchanger (sodium/hydrogen exchanger, NHE) family exchanges Na+ for H+ according to their concentration gradients, thus promotes the regulation of the stability of cytoplasmic pH and cell volume.
There are nine isoforms of NHE in humans, some NHEs function primarily on the plasma membrane, and others are present on intracellular organelles. NHE1 is expressed in the plasma membrane of virtually all tissues and plays an important role in cardiac health. NHE2 is expressed in the gastrointestinal (GI) tract and contributes to the maintenance of stomach pH and homeostasis, whereas NHE3 predominates in the GI tract and kidneys. NHE4 and NHE5 are abundant in the stomach and brain, respectively. NHE6-9 are expressed in the intracellular compartments of many organ system membranes, but of these NHE8 is the exception and expressed apically.
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Na+/H+ Exchanger (NHE) Related Products (54)
Related Products (54)
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NHE-1-IN-2
0 ImagesNHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. NHE-1-IN-2 alleviates left ventricular systolic dysfunction in mice model of heart failure.
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Rimeporide (Standard)
0 ImagesSynonyms: EMD-87580 (Standard)Rimeporide (Standard) is the analytical standard of Rimeporide. This product is intended for research and analytical applications. Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
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Zoniporide mesylate
0 ImagesCat. No.: HY-105064ACAS No.: 249296-45-5Synonyms: CP-597396 mesylateZoniporide mesylate (CP-597396 mesylate) is a selective Na+/H+ exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide mesylate reduces intracellular Na+ and Ca2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide mesylate is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury.
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FJ9
0 ImagesFJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC50 1540 μM, NHERF1 PDZ2 IC50 160 μM, and Frizzled-7-Dishevelled PDZ complex Ki 10 μM. FJ9 binds ligand-binding pockets of NHERF1 PDZ domains to block cognate ligand interactions, disrupts Frizzled-7-Dishevelled interactions, and down-regulates canonical Wnt signaling. FJ9 induces apoptosis in cancer cells with intact β-catenin signaling. FJ9 can be used for the research of non-small cell lung cancer, melanoma.
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Zoniporide hydrochloride
0 ImagesCat. No.: HY-105064BCAS No.: 241800-97-5Synonyms: CP-597396 hydrochlorideZoniporide hydrochloride (CP-597396 hydrochloride) is a selective Na+/H+ exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide hydrochloride reduces intracellular Na+ and Ca2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide hydrochloride is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury.
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NCX1-IN-1
0 ImagesCat. No.: HY-160508CAS No.: 2754283-55-9NCX1-IN-1 (Compound 6) is the inhibitor for Na+/Ca2+ exchanger(NCX).
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Zoniporide dihydrochloride
0 ImagesCat. No.: HY-105064CCAS No.: 241799-10-0Synonyms: CP-597396 dihydrochlorideZoniporide dihydrochloride (CP-597396 dihydrochloride) is a selective Na+/H+ exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide dihydrochloride reduces intracellular Na+ and Ca2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide dihydrochloride is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury.
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TY-51924 ethanol sodium
0 ImagesCat. No.: HY-19862CAS No.: 1614265-31-4TY-51924 ethanol sodium is a highly selective NHE-1 inhibitor (IC50 = 0.095 μM). TY-51924 ethanol sodium can significantly reduce the infarct size and myocardial enzyme release. TY-51924 ethanol sodium is commonly used in the study of ischemia-reperfusion injury.
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Sabiporide hydrochloride
0 ImagesCat. No.: HY-122525ACAS No.: 324758-66-9Synonyms: BIIB 722 hydrochlorideSabiporide hydrochloride is a NHE-1 inhibitor (Ki: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death.
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d9A1-2
0 ImagesCat. No.: HY-183892CAS No.: 2690350-15-1d9A1-2 is a potent SLC9A1 PROTAC degrader. d9A1-2 binds to SLC9A1 via the d9A1 warhead, recruits the CRL4CRBN E3 ubiquitin ligase through EBM, and thereby induces ubiquitination and proteasomal degradation of SLC9A1. d9A1-2 can be used for research on cancers such as acute myeloid leukemia.
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NHE3-IN-1
0 ImagesNHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.
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1,3,5-Trihydroxy-4-prenylxanthone
0 ImagesCat. No.: HY-N10156CAS No.: 53377-61-01,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities.
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FR168888
0 ImagesCat. No.: HY-123679CAS No.: 168620-46-0FR-168888 is a Na+/H+ exchanger (NHE) inhibitor (Ki=6.4 nM) with weak inhibitory activity against Na+/Ca2+ exchanger and no cardioprotective effects. FR-168888 is widely applicable to studies related to reperfusion-induced ventricular arrhythmias.
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Repunapanor
0 ImagesCat. No.: HY-177125CAS No.: 1870822-78-8Repunapanor (compound 123) is a potent Na+/H+ exchanger 3 (NHE-3) inhibitor.
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Eniporide mesylate
0 ImagesCat. No.: HY-106150ACAS No.: 190368-98-0Eniporide mesylate (EMD 96785 mesylate) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide mesylate specifically inhibits the NHE-1 isoform. Eniporide mesylate improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide mesylate regulates cardiac performance and high-energy phosphate content.
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KR-33028
0 ImagesCat. No.: HY-123659CAS No.: 861218-37-3KR-33028 is a selective NHE1 inhibitor. KR-33028 reduces hypoxia-induced necrosis and apoptosis in H9c2 cells. KR-33028 inhibits hypoxia-induced increases in cytoplasmic and mitochondrial Ca2+ levels and cytochrome c release. KR-33028 improves cardiac contractility, reduces lactate dehydrogenase release, and increases tissue ATP, creatine phosphate, and glycogen levels. KR-33028 can be used in research on cancers such as cardioblastoma and cardiovascular diseases such as ischemic stroke.
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FR183998 free base
0 ImagesFR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
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T 162559
0 ImagesCat. No.: HY-105402CAS No.: 339532-12-6T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC50 values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease.
