Na+/H+ Exchanger (NHE)

Sodium/hydrogen Exchanger; Sodium-hydrogen Exchanger

Na⁺/H⁺ exchanger (sodium/hydrogen exchanger, NHE) family exchanges Na⁺ for H⁺ according to their concentration gradients, thus promotes the regulation of the stability of cytoplasmic pH and cell volume.

There are nine isoforms of NHE in humans, some NHEs function primarily on the plasma membrane, and others are present on intracellular organelles. NHE1 is expressed in the plasma membrane of virtually all tissues and plays an important role in cardiac health. NHE2 is expressed in the gastrointestinal (GI) tract and contributes to the maintenance of stomach pH and homeostasis, whereas NHE3 predominates in the GI tract and kidneys. NHE4 and NHE5 are abundant in the stomach and brain, respectively. NHE6-9 are expressed in the intracellular compartments of many organ system membranes, but of these NHE8 is the exception and expressed apically.

Na+/H+ Exchanger (NHE) Related Products (52):

By Effects:	Inhibitors (47) Antagonists (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-150269

RS5517	Inhibitor
RS5517 is a specific PDZ1-domain antagonist of NHERF1 that prevented its ectopic nuclear entry. RS5517 can be used for the research of colorectal cancer.

HY-163365

UTX-143	Inhibitor
UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity.

HY-173517

NHE-1-IN-2	Inhibitor	99.57%
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC₅₀ of 0.78 μM. NHE-1-IN-2 alleviates left ventricular systolic dysfunction in mice model of heart failure.

HY-19273R

Rimeporide (Standard)	Inhibitor
Rimeporide (Standard) is the analytical standard of Rimeporide. This product is intended for research and analytical applications. Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).

HY-105064A

Zoniporide mesylate	Inhibitor
Zoniporide mesylate (CP-597396 mesylate) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na⁺ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease.

HY-105064B

Zoniporide hydrochloride	Inhibitor
Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM).

HY-160508

NCX1-IN-1	Inhibitor
NCX1-IN-1 (Compound 6) is the inhibitor for Na+/Ca2+ exchanger(NCX).

HY-105064C

Zoniporide dihydrochloride	Inhibitor
Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1). Zoniporide dihydrochloride inhibits NHE1 dependent 22Na⁺ uptake in vitro with an IC₅₀ of 14 nM. Zoniporide has antitumor activity.

HY-19862

TY-51924 ethanol sodium	Inhibitor
TY-51924 ethanol sodium is a highly selective NHE-1 inhibitor (IC₅₀ = 0.095 μM). TY-51924 ethanol sodium can significantly reduce the infarct size and myocardial enzyme release. TY-51924 ethanol sodium is commonly used in the study of ischemia-reperfusion injury.

HY-122525A

Sabiporide hydrochloride	Inhibitor
Sabiporide hydrochloride is a NHE-1 inhibitor (K_i: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death.

HY-100325

NHE3-IN-1	Inhibitor	98.05%
NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Inhibitor
1,3,5-Trihydroxy-4-prenylxanthone is a Na⁺/H⁺ exchange system inhibitor with a minimum inhibitory concentration of 10 μg/mL. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (HY-D1056)-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities.

HY-123679

FR168888	Inhibitor
FR168888 is an inhibitor of Na+/H+ exchange with a K_i value of 6.4 nM.

HY-177125

Repunapanor	Inhibitor
Repunapanor (compound 123) is a potent Na+/H+ exchanger 3 (NHE-3) inhibitor.

HY-106150A

Eniporide mesylate	Inhibitor
Eniporide mesylate (EMD 96785 mesylate) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide mesylate specifically inhibits the NHE-1 isoform. Eniporide mesylate improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide mesylate regulates cardiac performance and high-energy phosphate content.

HY-123659

KR-33028	Inhibitor
KR-33028 is a selective NHE1 inhibitor. KR-33028 reduces hypoxia-induced necrosis and apoptosis in H9c2 cells. KR-33028 inhibits hypoxia-induced increases in cytoplasmic and mitochondrial Ca²⁺ levels and cytochrome c release. KR-33028 improves cardiac contractility, reduces lactate dehydrogenase release, and increases tissue ATP, creatine phosphate, and glycogen levels. KR-33028 can be used in research on cancers such as cardioblastoma and cardiovascular diseases such as ischemic stroke.

HY-100302

FR183998 free base	Inhibitor	98.00%
FR183998 free base is a potent Na⁺/H⁺-exchange inhibitor, with IC₅₀s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pH_i change in rat lymphocytes, rat and human platelets, respectively.

HY-132181

Dimethylamiloride hydrochloride	Inhibitor
Dimethylamiloride hydrochloride is a Na⁺/H⁺ exchanger NHE inhibitor with K_i values of 0.02, 0.25, and 14 μM for NHE1, NHE2, and NHE3, respectively. Dimethylamiloride hydrochloride can be used for pain research.

HY-105402

T 162559	Inhibitor
T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC₅₀ values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease.

HY-118778

KR-32568	Inhibitor	99.80%
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC₅₀ of 230 nM. KR-32568 has cardioprotective effects.

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