Na+/H+ Exchanger (NHE) Inhibitor

Na+/H+ Exchanger (NHE) Inhibitors (47):

Cat. No.	Product Name	Effect	Purity

HY-101840

EIPA	Inhibitor	99.73%
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na⁺/H⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

HY-19693

Cariporide	Inhibitor	99.89%
Cariporide (HOE-642) is a selective Na⁺/H⁺ exchange inhibitor.

HY-15991

Tenapanor	Inhibitor	99.65%
Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia.

HY-105064A

Zoniporide mesylate	Inhibitor
Zoniporide mesylate (CP-597396 mesylate) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na⁺ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease.

HY-182624

FJ9	Inhibitor
FJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC₅₀ 1540 μM, NHERF1 PDZ2 IC₅₀ 160 μM, and Frizzled-7-Dishevelled PDZ complex K_i 10 μM. FJ9 binds ligand-binding pockets of NHERF1 PDZ domains to block cognate ligand interactions, disrupts Frizzled-7-Dishevelled interactions, and down-regulates canonical Wnt signaling. FJ9 induces apoptosis in cancer cells with intact β-catenin signaling. FJ9 can be used for the research of non-small cell lung cancer, melanoma.

HY-106150A

Eniporide mesylate	Inhibitor
Eniporide mesylate (EMD 96785 mesylate) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide mesylate specifically inhibits the NHE-1 isoform. Eniporide mesylate improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide mesylate regulates cardiac performance and high-energy phosphate content.

HY-15991A

Tenapanor hydrochloride	Inhibitor	99.55%
Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia.

HY-19273

Rimeporide	Inhibitor	98.63%
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na⁺/H⁺ exchanger (NHE-1).

HY-18071

BI-9627	Inhibitor	99.71%
BI-9627, a chemical probe, is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC₅₀ = 6 and 31 nM in intracellular pH recovery (pH_i) and human platelet swelling assays). BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 decreases autophagy in HTR-8/SVneo cells. BI-9627 can significantly reduce the pH_i of human sperm and partially reverse the effect of DMA. BI-9627 prolongs Ca²⁺ recovery time in KO hiPSC-CMs. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

HY-138866

Dimethylamiloride	Inhibitor	98.18%
Dimethylamiloride is a specific antiporter inhibitor.

HY-105064D

Zoniporide hydrochloride hydrate	Inhibitor	99.16%
Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM).

HY-106150B

Eniporide hydrochloride	Inhibitor	99.49%
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na⁺/H⁺ exchange inhibitor.

HY-156696

S3226	Inhibitor	99.65%
S3226 is a highly selective NHE-3 inhibitor (IC₅₀<1 μM) that specifically blocks NHE-3-mediated sodium transport. S3226 significantly inhibits blastocyst formation and expansion in mouse embryos, and reduces fluid and electrolyte reabsorption in rat proximal tubules in a dose-dependent manner. S3226 effectively alleviates ischemia-induced acute renal failure by improving renal function parameters, reducing renal tubular injury and restoring intracellular pH homeostasis, without interfering with the normal tubuloglomerular feedback response. S3226 is widely used in studies of acute renal failure and related pathological mechanisms.

HY-139313

NHE3-IN-2	Inhibitor	98.65%
NHE3-IN-2 is a Na⁺/H⁺ exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin).

HY-174400

SGLT2-IN-2	Inhibitor	99.57%
SGLT2-IN-2 (Compound E9) is an inhibitor of SGLT2. SGLT2-IN-2 significantly enhances the inhibition of SGLT2, NHE1, and SOD enzyme activity. SGLT2-IN-2 has protective effect on the glucose-free DMEM-induced injured cardiomyocytes. SGLT2-IN-2 significantly improves cardiac function in TAC-induced HF mice and inhibits cardiomyocyte hypertrophy as well as collagen deposition. SGLT2-IN-2 can ameliorate myocardial tissue damage and enhance mitochondrial autophagy in injured cardiomyocytes, thereby increasing survival rates in HF mice.

HY-105064

Zoniporide	Inhibitor	99.89%
Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na⁺ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease.

HY-18071A

BI-9627 hydrochloride	Inhibitor	98.01%
BI-9627 hydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC₅₀ = 6 and 31 nM in intracellular pH recovery (pH_i) and human platelet swelling assays). BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride decreases autophagy in HTR-8/SVneo cells. BI-9627 hydrochloride can significantly reduce the pH_i of human sperm and partially reverse the effect of DMA. BI-9627 hydrochloride prolongs Ca²⁺ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

HY-120623

BMS-284640	Inhibitor	99.75%
BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats..

HY-150269

RS5517	Inhibitor
RS5517 is a specific PDZ1-domain antagonist of NHERF1 that prevented its ectopic nuclear entry. RS5517 can be used for the research of colorectal cancer.

HY-163365

UTX-143	Inhibitor
UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity.

Name
Email *

	Sorry, but the email address you supplied was invalid.