Na+/H+ Exchanger (NHE) Inhibitor

Na+/H+ Exchanger (NHE) Inhibitors (20):

Cat. No.	Product Name	Effect	Purity

HY-101840

EIPA	Inhibitor	99.73%
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na⁺/H⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

HY-19693

Cariporide	Inhibitor	99.89%
Cariporide (HOE-642) is a selective Na⁺/H⁺ exchange inhibitor.

HY-15991

Tenapanor	Inhibitor	99.65%
Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia.

HY-105064C

Zoniporide dihydrochloride	Inhibitor
Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1). Zoniporide dihydrochloride inhibits NHE1 dependent 22Na⁺ uptake in vitro with an IC₅₀ of 14 nM. Zoniporide has antitumor activity.

HY-163365

UTX-143	Inhibitor
UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity.

HY-122525A

Sabiporide hydrochloride	Inhibitor
Sabiporide hydrochloride is a NHE-1 inhibitor (K_i: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death.

HY-19273

Rimeporide	Inhibitor	99.03%
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na⁺/H⁺ exchanger (NHE-1).

HY-18071

BI-9627	Inhibitor	≥99.0%
BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC₅₀s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

HY-105064D

Zoniporide hydrochloride hydrate	Inhibitor	≥99.0%
Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM).

HY-106150B

Eniporide hydrochloride	Inhibitor	98.97%
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na⁺/H⁺ exchange inhibitor.

HY-15991A

Tenapanor hydrochloride	Inhibitor	98.71%
Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia.

HY-18071A

BI-9627 hydrochloride	Inhibitor	98.01%
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

HY-139313

NHE3-IN-2	Inhibitor
NHE3-IN-2 is a Na⁺/H⁺ exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin).

HY-105064B

Zoniporide hydrochloride	Inhibitor
Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM).

HY-100325

NHE3-IN-1	Inhibitor	98.05%
NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Inhibitor
1,3,5-Trihydroxy-4-prenylxanthone is a Na⁺/H⁺ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC₅₀ value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities.

HY-100302

FR183998 free base	Inhibitor	98.00%
FR183998 free base is a potent Na⁺/H⁺-exchange inhibitor, with IC₅₀s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pH_i change in rat lymphocytes, rat and human platelets, respectively.

HY-132181

Dimethylamiloride hydrochloride	Inhibitor
Dimethylamiloride hydrochloride is a Na⁺/H⁺ exchanger NHE inhibitor with K_i values of 0.02, 0.25, and 14 μM for NHE1, NHE2, and NHE3, respectively. Dimethylamiloride hydrochloride can be used for pain research.

HY-118778

KR-32568	Inhibitor	99.80%
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC₅₀ of 230 nM. KR-32568 has cardioprotective effects.

HY-19273A

Rimeporide hydrochloride	Inhibitor
Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na⁺/H⁺ exchanger (NHE-1).

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