1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. BI-9627 hydrochloride

BI-9627 hydrochloride 

Cat. No.: HY-18071A
Handling Instructions

BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

For research use only. We do not sell to patients.

BI-9627 hydrochloride Chemical Structure

BI-9627 hydrochloride Chemical Structure

CAS No. : 1422252-46-7

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Description

BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1].

IC50 & Target

IC50: 6 nM (NHE1 in intracellular pH recovery assay), 31 nM (NHE1 in human platelet swelling assay)[1]

Molecular Weight

392.80

Formula

C₁₆H₂₀ClF₃N₄O₂

CAS No.

1422252-46-7

SMILES

NC(NC(C1=CC=C(C2CCN(C(C)=O)CC2)C(C(F)(F)F)=C1)=O)=N.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BI-9627BI9627BI 9627Sodium ChannelNa channelsNa+ channelsselectiveoralpharmacokineticsdrug-druginteractionischemia-reperfusioninjuryInhibitorinhibitorinhibit

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BI-9627 hydrochloride
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HY-18071A
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