1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Cariporide

Cariporide (Synonyms: HOE-642)

Cat. No.: HY-19693 Purity: 98.57%
Handling Instructions

Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor.

For research use only. We do not sell to patients.

Cariporide Chemical Structure

Cariporide Chemical Structure

CAS No. : 159138-80-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 270 In-stock
Estimated Time of Arrival: December 31
100 mg USD 440 In-stock
Estimated Time of Arrival: December 31
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Description

Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor.

In Vitro

Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na+ and Ca2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H2+O2+[1]. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca2+ in cardiac myocytes through inhibition of Na+/H+ exchange[2]. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1)[3].

In Vivo

Intravenous administration of cariporide significantly decreases brain Na+ uptake and reduces cerebral edema, brain swelling, and infarct volume[4].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (352.92 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5292 mL 17.6460 mL 35.2920 mL
5 mM 0.7058 mL 3.5292 mL 7.0584 mL
10 mM 0.3529 mL 1.7646 mL 3.5292 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Neonatal rat cardiomyocytes are randomly separated into groups: (1) control group, (2) incubation with 100 μM hydrogen peroxide, or (3) pretreatment with 10 μM cariporide for 20 minutes followed by 100 μM hydrogen peroxide. Caspase-3 activity is measured by detection of the cleavage of a colorimetric caspase-3 substrate, N-acetyl-Asp-Glu-Val-Asp-p-nitroaniline, using an assay kit[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[4]

Rats: Cariporide and/or bumetanide are administered intravenously (15 or 30 mg/kg in 2 to 4 doses, respectively, of 7.5 mg/kg) starting at 20 minutes before initiation of pMCAO. For neurologic outcome experiments, some rats are given cariporide and/or bumetanide by a single intraperitoneal injection[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

283.35

Formula

C₁₂H₁₇N₃O₃S

CAS No.

159138-80-4

SMILES

O=C(NC(N)=N)C1=CC=C(C(C)C)C(S(=O)(C)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Cariporide
Cat. No.:
HY-19693
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Cariporide

Cat. No.: HY-19693