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Cariporide (mesilate)

(Synonyms: HOE-642)
12 Cited Publications
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Based on 12 publication(s) in Google Scholar

Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1.

For research use only. We do not sell to patients.

  • CAS No.: 159138-81-5
  • Formula: C13H21N3O6S2
  • Molecular Weight:379.45
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Cariporide (mesilate) Chemical Structure
    Cariporide (mesilate) Chemical Structure
  • Experimental Validation Results for Cariporide (mesilate)
  • Experimental Validation Results for Cariporide (mesilate)
  • Experimental Validation Results for Cariporide (mesilate)
  • Experimental Validation Results for Cariporide (mesilate)
  • Experimental Validation Results for Cariporide (mesilate)
CAS No.: 159138-81-5
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Cariporide (mesilate) Chemical Structure
    Cariporide (mesilate) Chemical Structure
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    Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Oct 22:192:118670. [Abstract]

    Customer Validation
     To test the involvement of NHE1 and NCX in the ROS inhibition effect of EMPA, HCAECs were pre-incubated with either Vehicle, Cariporide (10 µM) or ORM-10962 (100 nM), in combination with EMPA or not, for 2 h before exposure to OSS. After 6 h, ROS was measured using live cell image and quantified with MFI.

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    Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2024 Aug 31:S0002-9440(24)00328-6. [Abstract]

    Customer Validation
     Statistical analysis showing the effect of Cariporide (10 μmol/L) on the enhanced pHi recovery induced by LPS (10 μg/mL) stimulation for 6 hours in VK2/E6E7 cells.

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    Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: JCI Insight. 2023 Oct 9;8(19):e170928. [Abstract]

    Customer Validation
     Immunocytochemistry of PDAC-like PSCs in the absence (left) or presence (right) of cariporide (CARI: 10 μM).

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    Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: JCI Insight. 2023 Oct 9;8(19):e170928. [Abstract]

    Customer Validation
     Immunocytochemistry of CAFs derived from KPfC mice after a 1-month treatment with vehicle or gemcitabine + Cariporide (3 mg/kg i.p.).

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    Cariporide (mesilate) purchased from MedChemExpress. Usage Cited in: Am J Physiol Heart Circ Physiol. 2024 Feb 1;326(2):H418-H425. [Abstract]

    Customer Validation
     original current traces of a control mdx (mdx DMSO), a cariporide-treated mdx (mdx CARI, 24-h incubation at 10 µM concentration), and a cariporide-plus EMPA-treated (mdx CARI + EMPA) cardiomyocyte.

  • Cariporide (mesilate)