2. Membrane Transporter/Ion Channel
  3. Na+/H+ Exchanger (NHE)
  4. UTX-143

UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity.

For research use only. We do not sell to patients.

UTX-143

UTX-143 Chemical Structure

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UTX-143 Related Antibodies

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Description

UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity[1].

IC50 & Target

NHE5[1]
Cellular Effect
Cell Line Type Value Description References
HT-1080 IC50
15.4 μM
Compound: 17; UTX-143
Cytotoxicity against human HT-1080 cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay
Cytotoxicity against human HT-1080 cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay
[PMID: 38246115]
NHDF IC50
>100 μM
Compound: 17; UTX-143
Cytotoxicity against HDF cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay
Cytotoxicity against HDF cells assessed as inhibition of cell growth incubated for 48 hrs by WST-8 assay
[PMID: 38246115]
TE-1 IC50
4.4 μM
Compound: 17; UTX-143
Cytotoxicity against human TE-1 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
Cytotoxicity against human TE-1 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
[PMID: 38246115]
TE-10 IC50
49.5 μM
Compound: 17; UTX-143
Cytotoxicity against human TE-10 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
Cytotoxicity against human TE-10 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
[PMID: 38246115]
TE-11 IC50
46.1 μM
Compound: 17; UTX-143
Cytotoxicity against human TE-11 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
Cytotoxicity against human TE-11 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
[PMID: 38246115]
TE-15 IC50
5.1 μM
Compound: 17; UTX-143
Cytotoxicity against human TE-15 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
Cytotoxicity against human TE-15 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
[PMID: 38246115]
TE-5 IC50
<3.1 μM
Compound: 17; UTX-143
Cytotoxicity against human TE-5 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
Cytotoxicity against human TE-5 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
[PMID: 38246115]
TE-6 IC50
22.6 μM
Compound: 17; UTX-143
Cytotoxicity against human TE-6 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
Cytotoxicity against human TE-6 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
[PMID: 38246115]
TE-9 IC50
24.6 μM
Compound: 17; UTX-143
Cytotoxicity against human TE-9 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
Cytotoxicity against human TE-9 cells expressing NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
[PMID: 38246115]
TMK-1 IC50
25.3 μM
Compound: 17; UTX-143
Cytotoxicity against human TMK-1 cells expressing HA-tagged full length human NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
Cytotoxicity against human TMK-1 cells expressing HA-tagged full length human NHE5 assessed as inhibition of cell growth incubated for 72 hrs by WST-8 assay
[PMID: 38246115]
Molecular Weight

343.38

Formula

C16H21N7O2
SMILES

O=C(NC(N)=N)C(N=C1C2=CC=C(C)C=C2)=C(N=C1N(CCO)C)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UTX-143 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UTX-143UTX143UTX 143Na+/H+ Exchanger (NHE)Sodium/hydrogen ExchangerSodium-hydrogen ExchangerAmilorideAnti-invasionAntitumorNHE5 inhibitorInhibitorinhibitorinhibit

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HY-163365
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