1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Rimeporide

Rimeporide (Synonyms: EMD-87580)

Cat. No.: HY-19273 Purity: 98.77%
Handling Instructions

Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).

For research use only. We do not sell to patients.

Rimeporide Chemical Structure

Rimeporide Chemical Structure

CAS No. : 187870-78-6

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 286 In-stock
Estimated Time of Arrival: December 31
1 mg USD 190 In-stock
Estimated Time of Arrival: December 31
5 mg USD 390 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Other Forms of Rimeporide:

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Description

Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).

IC50 & Target

NHE1[1]

In Vitro

Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent[1].

Clinical Trial
Molecular Weight

333.38

Formula

C₁₁H₁₅N₃O₅S₂

CAS No.

187870-78-6

SMILES

O=C(NC(N)=N)C1=CC(S(=O)(C)=O)=C(S(=O)(C)=O)C=C1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (59.99 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9996 mL 14.9979 mL 29.9958 mL
5 mM 0.5999 mL 2.9996 mL 5.9992 mL
10 mM 0.3000 mL 1.4998 mL 2.9996 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

RimeporideEMD-87580EMD87580EMD 87580Sodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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Rimeporide
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