RS5517
Based on 1 Customer Validation
RS5517 is a specific PDZ1-domain antagonist of NHERF1 that prevented its ectopic nuclear entry. RS5517 can be used for the research of colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 95.79%
- CAS No.: 2227017-46-9
- Formula: C23H19ClN2O2
- Molecular Weight:390.86
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Membrane Transporter/Ion Channel Compound Library
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Anti-Cancer Compound Library
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Anti-Colorectal Cancer Compound Library
HY-L103
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
HY-L150
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
0.1 μM
Compound: 15
|
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
|
[PMID: 30996786] |
| DLD-1 | IC50 |
0.5 μM
Compound: 15
|
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of FH535 by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of FH535 by MTT assay
|
[PMID: 30996786] |
| DLD-1 | IC50 |
65 μM
Compound: 15
|
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs by MTT assay
|
[PMID: 30996786] |
| LS174T | IC50 |
52 μM
Compound: 15
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Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by absence of doxycycline by MTT assay
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by absence of doxycycline by MTT assay
|
[PMID: 30996786] |
| LS174T | IC50 |
8 μM
Compound: 15
|
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by presence of doxycycline by MTT assay
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by presence of doxycycline by MTT assay
|
[PMID: 30996786] |
| SW480 | IC50 |
0.1 μM
Compound: 15
|
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
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[PMID: 30996786] |
| SW480 | IC50 |
0.9 μM
Compound: 15
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Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
|
[PMID: 30996786] |
| SW480 | IC50 |
8 μM
Compound: 15
|
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs by MTT assay
|
[PMID: 30996786] |
| SW-620 | IC50 |
0.5 μM
Compound: 15
|
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
|
[PMID: 30996786] |
| SW-620 | IC50 |
18 μM
Compound: 15
|
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
|
[PMID: 30996786] |
Chemical Information
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CAS No. 2227017-46-9
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Appearance Solid
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Molecular Weight 390.86
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Formula C23H19ClN2O2
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Color White to light yellow
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SMILES
O=C(C1=C(CC2=CC=CC=C2)C3=C(C=CC(Cl)=C3)N1)NC4=CC=C(CO)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Saponaro C, et al. β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. Oncogene. 2018 Jun;37(24):3301-3316. doi: 10.1038/s41388-018-0170-y. Epub 2018 Mar 19. [Content Brief]
[2]. Capdevielle C, et al. HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53. Neuro Oncol. 2020 Apr 15;22(4):550-562. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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