T 162559 

T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC₅₀ values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease^[1].

T-162559 (10-100 nmol/L, continuous infusion started 10 minutes before the induction of global ischemia) concentration-dependently inhibits the reduction in cardiac contractility, progression of cardiac contracture, and increase in lactate dehydrogenase release after global ischemia and reperfusion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

T-162559 (0.03-0.1 mg/kg, i.v., 5 mins before coronary occlusion) significantly inhibits the progression of myocardial infarction induced by left coronary artery occlusion and reperfusion in rabbits^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

517.59

C₂₀H₂₈FN₅O₆S₂

339532-12-6

CS(=O)(O)=O.CS(=O)(O)=O.CC1=C([C@@H]2C/C(C3=C(C)C=CN=C3C2)=N\NC(N)=N)C=C(F)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kawamoto T, et al. Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559. Eur J Pharmacol. 2001 May 18;420(1):1-8.  [Content Brief]

  [2]. Kusumoto K, et al. In vitro and in vivo pharmacology of a structurally novel Na+-H+ exchange inhibitor, T-162559. Br J Pharmacol. 2002 Apr;135(8):1995-2003.  [Content Brief]